Effect on the Time Course of the Cerebral Prostaglandin Dehydrogenase in Pyretic Rats by Guizhi Tang
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Effect on the Time Course of the Cerebral Prostaglandin Dehydrogenase in Pyretic Rats by Guizhi Tang
Chinese Journal of Experimental Traditional Medical FormulaeVol. 10, Issue 1, Pages: 22-25(2004)
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Published:2004
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LI Cang-hai, Zhou Jun, Huo Hai-ru, et al. Effect on the Time Course of the Cerebral Prostaglandin Dehydrogenase in Pyretic Rats by Guizhi Tang[J]. Chinese journal of experimental traditional medical formulae, 2004, 10(1): 22-25.
DOI:
LI Cang-hai, Zhou Jun, Huo Hai-ru, et al. Effect on the Time Course of the Cerebral Prostaglandin Dehydrogenase in Pyretic Rats by Guizhi Tang[J]. Chinese journal of experimental traditional medical formulae, 2004, 10(1): 22-25.DOI:
Effect on the Time Course of the Cerebral Prostaglandin Dehydrogenase in Pyretic Rats by Guizhi Tang
Objective:To investigate the effect of Guizhi Tang on the time course of cerebral 15 hydroxy prostaglandin dehydrogenase(15-PGDH)in pyretic rats. Methods: The activity of 15-PGDH in hypothalamus and the other cerebral tissues at different time in rats were measured using radio-TLC assay. Results: Paralleled to a fever response induced by a s.c.injection of yeast
the activity of 15-PGDH decreased first
then followed by a gradual return to baselime. Treatment with Guizhi Tang inhibited the decrease of PGDH activity and enhanced it to above normal level;similar changes appeared to the other cerebral tissues while the recover in the later phase was inhibited by Guizhi Tang. Conclusion: Present data suggest that the decrease of the PGDH activity in hypothalamus may contribute to the early stage of fever-induction by yeast in rats and the increase of the enzyme may be one of the antipyretic mechanisms of Guizhi Tang.
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GUO Shu-ying
Qi Yun
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Li Cang-hai1
HUO Hai-ru1
LI Lan-fang1
JIANG Nan1
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Key Laboratory of Chinese Medicine Resource and Compound Prescription, Ministry of Education, Hubei University of Chinese Medicine
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