Effects of Lingguizhugan Decoction on T-lymphocyte Subset and the Activity of Interleukin-2 in Immunosuppuressed Mice Induced by Cyclophosphamide
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Effects of Lingguizhugan Decoction on T-lymphocyte Subset and the Activity of Interleukin-2 in Immunosuppuressed Mice Induced by Cyclophosphamide
Chinese Journal of Experimental Traditional Medical FormulaeVol. 9, Issue 6, Pages: 38-40(2003)
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Published:2003
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HUANG Jin-ling, LONG Zi-jiang, WU Hua-qiang, et al. Effects of Lingguizhugan Decoction on T-lymphocyte Subset and the Activity of Interleukin-2 in Immunosuppuressed Mice Induced by Cyclophosphamide[J]. Chinese journal of experimental traditional medical formulae, 2003, 9(6): 38-40.
DOI:
HUANG Jin-ling, LONG Zi-jiang, WU Hua-qiang, et al. Effects of Lingguizhugan Decoction on T-lymphocyte Subset and the Activity of Interleukin-2 in Immunosuppuressed Mice Induced by Cyclophosphamide[J]. Chinese journal of experimental traditional medical formulae, 2003, 9(6): 38-40.DOI:
Effects of Lingguizhugan Decoction on T-lymphocyte Subset and the Activity of Interleukin-2 in Immunosuppuressed Mice Induced by Cyclophosphamide
Objiecteve:To study Immunoregulating mechanism of Lingguizhugan Decoction on immunosuppression in mice.Methods:The immunosuppressed mice were induced by cyclophoamide (Cy)
80mg·kg-1
ip
qd×1.Lingguizhugan Decoctine (42.90
21.45
4.29g·kg-1
ig
qd×10) were administrated for immunosuppressed mice.Then the T-lymphocyte subset and activity of interleukin-2(IL-2) were measured by indirect immunofluorescence and thymus cells intermingled 3H-TdR.Ressults:Lingguizhugan Decoction could obviously enhance the total number of T-cells
percentage of L3T+4
Lyt-2+ and revise the turbulence of T-lymphocyte subset.It could also evidently promote the activity of IL-2.Conclusion:The Immunoregulating mechanism of Lingguizhugan Decoction in immunodepression mice were related with promoting the function of helper T-cell(TH) and activity of IL-2.