An Experimental Study on the Inhibiting Effect of Shenmai Injection on Endothelial Cell Proliferation and Migration
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An Experimental Study on the Inhibiting Effect of Shenmai Injection on Endothelial Cell Proliferation and Migration
Chinese Journal of Experimental Traditional Medical FormulaeVol. 9, Issue 2, Pages: 30-32(2003)
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Published:2003
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DING-Zhi-san, GAO Cheng-xian, YIN Li-hui, et al. An Experimental Study on the Inhibiting Effect of Shenmai Injection on Endothelial Cell Proliferation and Migration[J]. Chinese journal of experimental traditional medical formulae, 2003, 9(2): 30-32.
DOI:
DING-Zhi-san, GAO Cheng-xian, YIN Li-hui, et al. An Experimental Study on the Inhibiting Effect of Shenmai Injection on Endothelial Cell Proliferation and Migration[J]. Chinese journal of experimental traditional medical formulae, 2003, 9(2): 30-32.DOI:
An Experimental Study on the Inhibiting Effect of Shenmai Injection on Endothelial Cell Proliferation and Migration
Object:To study the effects of Shenmai injection on angiogenesis. Methods:Proliferation of bovine aortic endothelial cells(BAECs) were measured by MTT colorimetric assay after treated by various concentrations of Shenmai injection. The effects of Shenmai injection on proliferation of BAECs induced by conditioned medium of tumor(CM) were also measured by the same method. The effect of various concentrations of Shenmai on the migration of BAECs induced by fetal bovine serurm(FBS) or CM was investigated by agarose assay. Results:Shenmai injection significanly inhibited proliferation of BAECs induced by FBS or CM. And Shenmai injection inhibited the proliferation of BAECs in a dose-dependent manner. Shenmai injection inhibited migration of BAECs induced by FBS or CM. Conclusion:Shenmai injection can inhibit proliferation and migraion of bovine aortic endothelial cells. It is suggested that Shenmai can suppress angiogenesis.