Objective: To observe the effects of drug couples of Bupleurum Root and Red Peony Root(BRP)

Vinegar-baked Bupleurum Root and White Peony Root(VBWP) on hyperipemia in rats. Methods: The hyperlipemia and blood stasis rat model were established by high-cholesterol diet and adnephrin injection. The changes of the lipid metabolism and platelet function were observed in differot groups. Results: In comparison with the control group

the VBWP and BRP groups reduced TC significatly

espesialy VBWP is more significant. Reduction in LDL-C

LP (a)in these groups was found(P<0.05 or p<0.01) that they are more significant in the BRP.The VBWP groups reduced TG (P<0.01). The VBWP groups inhibited the platelet activation and reduced the platelet aggregation (P<0.05). Conclusions: The BRP and VBWP had different mechanisms in regulation of atherosclerosis. Further studies are needed for elucidating the mechanism.