Clinical Research of Zhinao Capsule on 60 Cases with Vascular Dementia

YANG Wen-ming1; HU Wen-juan2; HAN Ming-xiang1; ZHOU Yi-xuan1; -BAO Yun-cheng1; WU Jian-song3; XU Han-mei1

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Clinical Research of Zhinao Capsule on 60 Cases with Vascular Dementia

更新时间：2024-01-04

- Clinical Research of Zhinao Capsule on 60 Cases with Vascular Dementia
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 8, Issue 6, Pages: 48-50(2002)
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- Published：2002
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YANG Wen-ming1, HU Wen-juan2, HAN Ming-xiang1, et al. Clinical Research of Zhinao Capsule on 60 Cases with Vascular Dementia[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(6): 48-50.
DOI：

YANG Wen-ming1, HU Wen-juan2, HAN Ming-xiang1, et al. Clinical Research of Zhinao Capsule on 60 Cases with Vascular Dementia[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(6): 48-50. DOI：

摘要

目的:观察智脑胶囊治疗血管性痴呆(VaD)的临床疗效。方法:将90例病人随机单盲分为二组。治疗组(60例)采用智脑胶囊治疗

对照组(30例)给予喜得镇口服。结果:智脑胶囊总有效率为63.3%

对照组总有效率为53.3%。两组疗效无明显差异。但在改善中医临床证候及血液流变学指标方面优于后者

同时智脑胶囊还能提高MMSE、HDS-R积分值

降低ADL、神经功能缺损积分值

改善脑血流及异常脑电活动

两组差异无显著性。结论:智脑胶囊对VaD的治疗有一定的改善作用。

Abstract

Objective:To evaluate the curable effect of Zhinao capsule in treatment of vascular dementia (VaD). Methods: 90 cases of VaD were divided randomly into two groups with single-blind method

60 cases were administered with Zhinao capsule as treatment group

30 cases were treated with Hydergine orally as control group. Results: The total effective rate in the treatment group were 63.3%

whereas in the control group were 53.3%. The differences between two groups were not significant. On the other hand

the effect of the treatment group in improving indexes of TCM syndromes and hemorrheology was superior to the control group. In the meantime

the treatment group could increase the scores of minin-mental state examination (MMSE) and Hasegawa's dementia scale-revision (HDS-R)

reduce the scores of activities of daily living (ADL) and neural functional defect

and improve cerebral blood-flow and abnormal electroencephalograph

There were not significant differences between the two groups. Conclusion: Zhinao capsule exerts a certain effect on VaD.

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Related Author

YANG Wen-ming

WANG Shi-guang

BAO Yuan-cheng

YANG Xing-tao

ZHANG Bo

WANG Mei-xia

DONG Ting

YANG Wen-ming

Related Institution

安徽中医学院第一附属医院安徽合肥230031

Hubei Shizhen Laboratory

The First Clinical Medical School，Hubei University of Chinese Medicine

Hubei Provincial Hospital of Traditional Chinese Medicine（TCM）

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