Experimental Study of Qibaomeirandan on Ultrastructure and Synapse Interface Configuration of Neurons in Aged Mice

QU Yan-hui1; WEN Chang-hu1; ZHIANG Liu-tong2; MEI Jia-jun2; XU Xi-ping3; WEN Le-xi1; TAN Gong-en1

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Experimental Study of Qibaomeirandan on Ultrastructure and Synapse Interface Configuration of Neurons in Aged Mice

更新时间：2024-01-04

- Experimental Study of Qibaomeirandan on Ultrastructure and Synapse Interface Configuration of Neurons in Aged Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 8, Issue 4, Pages: 24-27(2002)
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- Published：2002
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QU Yan-hui1, WEN Chang-hu1, ZHIANG Liu-tong2, et al. Experimental Study of Qibaomeirandan on Ultrastructure and Synapse Interface Configuration of Neurons in Aged Mice[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(4): 24-27.
DOI：

QU Yan-hui1, WEN Chang-hu1, ZHIANG Liu-tong2, et al. Experimental Study of Qibaomeirandan on Ultrastructure and Synapse Interface Configuration of Neurons in Aged Mice[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(4): 24-27. DOI：

摘要

探讨七宝美髯丹对老龄鼠前额皮质、海马CA1区神经元超微结构和突触界面结构参数的影响

与老年组比较

七宝美髯丹组神经元脂褐素含量减少

细胞膜及线粒体结构清晰。老年对照组粗面内质网脱颗粒

胞浆聚集

脂褐素电子密度增大

核糖体与粗面内质网减少

神经元与线粒体平均密度降低

线粒体平均体积明显增加且肿胀

而且空泡化。海马CA1区突触后膜致密物质(PSD)

活性区长度与突触界面曲率显著增大

突触间隙宽度显著变窄

Abstract

To explore the effect of Qibaomeirandan on the ultrastructure changes of preforntal cortex and Synapse in-terface Configuration in hippocampus CA1 area in aged mice

we used electron microscopy observing structural changes in hippocampus CA1 area.The content of lipofuscin in the neurons region of the experiment group was reduced as compared with thatofthe aged group.The structure

such asmembrane

ridges

ofthe mitochondrionwas clearlyseen in hippocampus neuron inQibaomeirandan group.The average density of neurons in the forehead cortex and CA1 hippocampus area showed shrinkage with the aging.So were the number of ribosomes and rough endoplasmic reticulum.The mitochondrion average volume showed some increase with aging.Postsynaptic density

active zones

curvature of synaptic interface

showed some increase and the synaptic cleftwidth showed some decrease with aging.

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Related Institution

Shanxi Hospital of Integrated Traditional and Western Medicine

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Traditional Chinese Medicine （Zhong Jing ）School，Henan University of Chinese Medicine

Jiangxi University of Chinese Medicine

The Affiliated Hospital of Jiangxi University of Chinese Medicine

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