Experimental Study of Immune Function on Monkey of SIV Infection with Zhong Yan-Ⅰand Zhong Yan-Ⅱ

XU Shu-ling; GUAN Chong-fen; WANG Hui; WENG Xn-yu

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Experimental Study of Immune Function on Monkey of SIV Infection with Zhong Yan-Ⅰand Zhong Yan-Ⅱ

更新时间：2024-01-04

- Experimental Study of Immune Function on Monkey of SIV Infection with Zhong Yan-Ⅰand Zhong Yan-Ⅱ
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 7, Issue 6, Pages: 32-34(2001)
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- Published：2001
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XU Shu-ling, GUAN Chong-fen, WANG Hui, et al. Experimental Study of Immune Function on Monkey of SIV Infection with Zhong Yan-Ⅰand Zhong Yan-Ⅱ[J]. Chinese journal of experimental traditional medical formulae, 2001, 7(6): 32-34.
DOI：

XU Shu-ling, GUAN Chong-fen, WANG Hui, et al. Experimental Study of Immune Function on Monkey of SIV Infection with Zhong Yan-Ⅰand Zhong Yan-Ⅱ[J]. Chinese journal of experimental traditional medical formulae, 2001, 7(6): 32-34. DOI：

摘要

目的:中研Ⅰ、Ⅱ号复方对恒河猴感染SIVmac、SIVmac251实验观察T、B淋巴细胞增殖

血清β2-MG含量

T细胞亚群变化的实验研究。方法:以猴免疫缺陷病毒SIVmac及SIVmac251感染猴

检测猴T、B细胞增殖变化

对感染猴血清β2-MG含量测定及对外周血CD4+T细胞百分数检测

观察中研Ⅰ、Ⅱ号对感染动物免疫调节作用和对免疫功能的影响。结果:中研Ⅰ号能提高感染动物T、B细胞增殖。中研Ⅱ号提高模型动物CD4+T细胞百分比

并降低动物血清β2-MG含量。结论:中研Ⅰ、Ⅱ号复方均能提高感染动物免疫功能

并对动物免疫细胞有保护作用。

Abstract

In order to research the effect of ZY-Ⅰ and ZY-Ⅱ on simian immunodeficiency virus (SIV mac and SIV mac251)

we used SAIDS model to observe the influence of T and B cell proliferation induced by mitogens before and after treatment with ZY-Ⅰ. Using monoclonal antibody to label on CD4+ T cells in PBMC with indirect immunofluorescence

the percentage was analyzed by flow cytometry. Serum β2 microglobin (β2MG) was measured by ELISA in ZY-Ⅱ group. Results indicate that ZY-Ⅰ enhanced the proliferation of T and B cells induced by mitogen

CD4+ T cells were increased in PBMC

and serum β2 MG level was decreased by ZY-Ⅱ.

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