Synergistic Antithrombotic Action Between Astragalosides And Total Saponins Of Paeonia

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Synergistic Antithrombotic Action Between Astragalosides And Total Saponins Of Paeonia

更新时间：2024-01-04

- Synergistic Antithrombotic Action Between Astragalosides And Total Saponins Of Paeonia
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 8, Issue 3, Pages: 35-37(2002)
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- Published：2002
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Synergistic Antithrombotic Action Between Astragalosides And Total Saponins Of Paeonia[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(3): 35-37.
DOI：

Synergistic Antithrombotic Action Between Astragalosides And Total Saponins Of Paeonia[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(3): 35-37. DOI：

摘要

运用肺栓塞、动脉血栓形成、脑血栓形成三种实验性血栓形成模型

观察黄芪总皂苷(AS)和赤芍总苷(TSP)以各种剂量配伍时的作用;结果AS和TSP均具有不同程度抗各种实验性血栓形成作用或趋势

配伍后作用更佳

抗凝作用则源于赤芍总苷

应用二因素五水平均匀设计方法观察到AS50mg/kg和TSP150mg/kg配伍时抗动脉血栓形成作用最佳

该剂量下两药配伍对于大鼠脑血栓有相加的保护作用。表明AS和TSP有协同抗血栓形成作用。

Abstract

Objective:To investigate the interactions between astragalosides (AS) and total saponins of paeonia(TSP) with various dosage. Methods:Using pulmonary embolism

artery thrombosis and cerebral thrombosis experimental thrombosis models. Results and Conlusion:AS and TSP showed apparent anti-thrombosis effects

and better when they were used together. The anti-thrombotic effects on artery thrombosis were the strongest when AS at dose of 50mg/kg co-operated with TSP at dose of 150mg/kg with uniform design method.

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Related Author

LUO Yong-ming3

LI Jun2

LI Li2

REN Zhou-xin1

Wei SHI

Fang FANG

Xiao-wei JIN

Related Institution

First Clinical College, Guangxi University of Chinese Medicine

Fangcun Branch of Guangdong Province Hospital of Traditional Chinese Medicine

Yunnan Cancer Hospital

Beijing Rongchang Medicin R&D Institute,Beijng

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