Objective:To investigate the effect of BuYanHanWu (BYHW) Tang upon infarction

vessel damage penumbra (VDP)

fibrinolytic system activity and endothelin.Methods:BYHW Tang consists of two parts

invigorationg Qi section (IQs) and promoting blood flow section (PBFs).To utilize the model of cold photochemical initiation of thrombosis to observe the effects of the whole of BYHW Tang

IQs and PBFs

respectively

on infarction size

VDP size

degree of vessel damage

localized cerebral blood flow

plasma tissue plasminogen activator(t-PA)

plasminogen activator in hibitor (PAI) and plasma endothelin content.Result:BYHW Tang influences all indexes significantly.IQs and PBFs both have the actions of limiting infarction size and degree of vessel damage

promoting of cerebral blood flow and inhibiting PAI activity.On the other hand

reducing the size of VDP and increasing the activity of t-PA by BYHW Tang come mainly from IQs

and the effect of reducing ET content is based on PBFs.Conclusion:The IQs is emphasized in the priscription of BYHW Tang.It can enhance the activity of fibrinolytic system and reduce the VIP size.The result hints BYHQ Tang is not only formulated for stroke caused by deficiency of Qi

but also effective for the treatment of ischemic stroke.