Experimental Study on the Analgesia Mechanism of Paeornia and Glycyrrhiza Dicoction

FENG Liang-yuan; YAN Shun-qin; WU Shu-qin; ZHANG Lu-jun

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Experimental Study on the Analgesia Mechanism of Paeornia and Glycyrrhiza Dicoction

更新时间：2024-01-04

- Experimental Study on the Analgesia Mechanism of Paeornia and Glycyrrhiza Dicoction
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 8, Issue 1, Pages: 23-25(2002)
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- Published：2002
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FENG Liang-yuan, YAN Shun-qin, WU Shu-qin, et al. Experimental Study on the Analgesia Mechanism of Paeornia and Glycyrrhiza Dicoction[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(1): 23-25.
DOI：

FENG Liang-yuan, YAN Shun-qin, WU Shu-qin, et al. Experimental Study on the Analgesia Mechanism of Paeornia and Glycyrrhiza Dicoction[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(1): 23-25. DOI：

摘要

应用福尔马林致痛法研究芍药甘草汤镇痛作用

并测定冰醋酸致痛小鼠血清和脊髓中一氧化氮(NO

催化光度法)、前列腺素E2(PGE2)含量及超氧化物歧化酶(SOD

紫外分光光度法)的活性

以分析其镇痛作用机理。结果显示:(1)福尔马林法致痛实验中

Ⅰ相和Ⅱ相反应结果

揭示芍药甘草汤既能抑制外周神经末梢引起的疼痛又能抑制继发的炎性反应所致的疼痛;(2)芍药甘草汤能明显降低造模小鼠血清和脊髓中NO、PGE2含量

增强SOD活力。结论:(1)芍药甘草汤对中枢和外周神经末梢均有镇痛作用;(2)芍药甘草汤镇痛作用与NO、PGE2和SOD均有关。

Abstract

The analgesia action was investigated in the pain model caused by formalin

and the content of NO

PGE2 and SOD of serum and spinal cord of mice with pain model caused by glacialaceticacid were also detected to study analgesia mechanism of Paeonia and Glycyrrhiza Decoction(PGD).The results indicate:(1)In Formalin pain experiment

PGD could restrain peripheral nerve twig action

and inhibit subesequent inflammatory reaction to ease pain in Ⅰ and Ⅱ phase reaction;(2)PGD could decrease the content of NO and PGE2 of serum and spinal cord of the mice and distinctly enhance the activity of SOD.

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