The Protective Effect of Yi-Xin-Kang Capsule-containing Serum on Mitochondria Injury Induced by Oxygen Stress

HANG Ling1; CHEN Ke-ji2

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The Protective Effect of Yi-Xin-Kang Capsule-containing Serum on Mitochondria Injury Induced by Oxygen Stress

更新时间：2024-01-04

- The Protective Effect of Yi-Xin-Kang Capsule-containing Serum on Mitochondria Injury Induced by Oxygen Stress
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 7, Issue 3, Pages: 25-28(2001)
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- Published：2001
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HANG Ling1, CHEN Ke-ji2. The Protective Effect of Yi-Xin-Kang Capsule-containing Serum on Mitochondria Injury Induced by Oxygen Stress[J]. Chinese journal of experimental traditional medical formulae, 2001, 7(3): 25-28.
DOI：

HANG Ling1, CHEN Ke-ji2. The Protective Effect of Yi-Xin-Kang Capsule-containing Serum on Mitochondria Injury Induced by Oxygen Stress[J]. Chinese journal of experimental traditional medical formulae, 2001, 7(3): 25-28. DOI：

摘要

目的和方法:应用羟自由基损伤体系(Fe2+/H2O2)在体外与大鼠心肌线粒体共同孵育30min

观察了氧应激对心肌线粒体的影响

探讨益心康胶囊(H303)含药血清对氧应激损伤的保护机制。结果:不同浓度Fe2+/H2O2可使反应体系中脂质过氧化产物明显升高;线粒体超微结构发生明显改变;线粒体肿胀度增加;线粒体GSH含量明显降低。H303含药血清可明显减轻上述损伤

表现为显著抑制线粒体脂质过氧化和GSH含量的降低;改善线粒体超微结构

减轻线粒体肿胀度。结论:氧应激可造成心肌线粒体结构和功能损伤。H303抗心肌缺血损伤的作用机制是通过防止线粒体脂质过氧化

保护内源性抗氧化物

改善线粒体结构等作用而实现的。

Abstract

The effect of oxygen stress on myocardial mitochondria of rat and the protective effect of Yi-Xin-Kang capsule(H303)-containing serum on oxygen stress-induced injury by incubating myocardial mitochondria with hydroxy free radical generating system (Fe2+/H2O2) for 30 min

were observed.Result shows Fe2+/H2O3 induced obvious injury of mitochondria concentration-dependently.It was also found that mitochondria were significantly occurred with lipid peroxidation and swelled

the ultrastructures of mitochondria were changed and the content of GSH was markedly reduced.H303-containing serum showed significant protective effects on mitochondria injury induced by oxygen stress

and antagonized mitochondria lipid peroxidation and the decrease of endogenous GSH.The ultrastuctures of mitochondria and their swelling degree were also improved.

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Related Author

HAN Ling1

ZHANG Haotian

QIU Yebei

SU Ran

YAN Xianxin

MA Min

LIN Taoxiu

ZHANG Wenjuan

Related Institution

The First Affiliated Hospital， Jinan University

School of Traditional Chinese Medicine， Jinan University

Beijing University of Chinese Medicine Third Affiliated Hospital

Changhai Hospital， Naval Medical University

School of Pharmacy，Anhui University of Chinese Medicine & Laboratory of Rearch and Development of Traditional Chinese Medicine in Anhui Province

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