Effect of Zhinao Capsule on Learning and Memory, and Cholinergic Transmitters in Cerebral Cortex and Hippocampus in Experimental AD Model Rats

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Effect of Zhinao Capsule on Learning and Memory, and Cholinergic Transmitters in Cerebral Cortex and Hippocampus in Experimental AD Model Rats

更新时间：2024-01-04

- Effect of Zhinao Capsule on Learning and Memory, and Cholinergic Transmitters in Cerebral Cortex and Hippocampus in Experimental AD Model Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 8, Issue 2, Pages: 21-24(2002)
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- Published：2002
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Effect of Zhinao Capsule on Learning and Memory, and Cholinergic Transmitters in Cerebral Cortex and Hippocampus in Experimental AD Model Rats[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(2): 21-24.
DOI：

Effect of Zhinao Capsule on Learning and Memory, and Cholinergic Transmitters in Cerebral Cortex and Hippocampus in Experimental AD Model Rats[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(2): 21-24. DOI：

摘要

观察智脑胶囊对实验性AD模型大鼠学习记忆及大脑皮层和海马结构区胆碱能神经递质的影响。方法:在采用β-淀粉样蛋白β-AP大鼠侧脑室注射联用转移生长因子β1(TGFβ1)脑内注射改进制作出实验性AD大鼠模型的基础上

应用避暗法和水迷路法测定AD模型大鼠学习记忆功能

并采用放射免疫法测定实验性AD模型大鼠大脑皮层和海马结构区乙酰胆碱含量、乙酰胆碱转移酶和乙酰胆碱酯酶活性。结果:经改进由β-AP联用TGFβ1诱导的实验性AD模型大鼠表现有明显的学习记忆障碍

同时模型大鼠大脑皮层和海马结构区Ach含量降低、ChAT活性下降、AchE活性升高。智脑胶囊能有效地改善实验性AD模型大鼠学习记忆功能

提高模型大鼠大脑皮层和海马结构区Ach含量和ChAT活性

降低AchE活性。结论:智脑胶囊可通过调节脑内胆碱能神经递质明显提高实验性AD模型大鼠学习记忆能力。

Abstract

Object:To observe the effect of Zhinao capsule on learning and memory

and cholinergic transmitter in cerebral cortex and hippocampus in experimental AD model rats. Methods: β-amyloid protein (β-AP) injection into lateral ventricle in rats and transforming growth factor β1(TGF β1) injection into the rat's brain tissue were applied to successfully make experimental rat model of AD on the basis of the document's experiment method improved. Step-through test and water-maze test were employed to investigate the function of learning and memory in AD model rats

and radioimmunoas-say was used to assay the activity of choline acetyltransferase (ChAT) and acetylcholinesterase (AchE)

and content of acetylcholine (Ach) in cerebral cortex and hippocampus of AD model rats. Results: There obviously are impairment of learning and memory in rats of AD model induced by β-AP and TGF β1. The activity of ChAT and content of Ach was lower

and activity of AchE was higher in AD model rats than that of normal rats. Zhinao capsule could improve the impairment of learning and memory

increase the content of Ach by raising the activity of ChAt and reducing the activity of AchE in the cerebral cortex and hippocampus of AD model rats. Conclusions: Zhinao capsule can markedly enhance the function of learning and memory of rats of AD model induced by β-AP and TGF β1 by regulating cholinergic transmitter in the cerebral cortex and hippocampus of AD model rats.

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