Effects on Platelet Aggregation and Adhesion,TXA and PGI of Plasma of Fufangdanshenfang in Normal Rabbits

QIN Cai-ling1; LIU Ting1; Zhang Yi1; SUN You-fu1; ZHANG Shu-yun1; ZHANG Bo-li2

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Effects on Platelet Aggregation and Adhesion,TXA and PGI of Plasma of Fufangdanshenfang in Normal Rabbits

更新时间：2024-01-04

- Effects on Platelet Aggregation and Adhesion,TXA and PGI of Plasma of Fufangdanshenfang in Normal Rabbits
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 8, Issue 3, Pages: 18-19(2002)
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- Published：2002
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QIN Cai-ling1, LIU Ting1, Zhang Yi1, et al. Effects on Platelet Aggregation and Adhesion,TXA and PGI of Plasma of Fufangdanshenfang in Normal Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(3): 18-19.
DOI：

QIN Cai-ling1, LIU Ting1, Zhang Yi1, et al. Effects on Platelet Aggregation and Adhesion,TXA and PGI of Plasma of Fufangdanshenfang in Normal Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(3): 18-19. DOI：

摘要

采用半体内实验方法

观察了复方丹参方对正常家兔血浆血小板聚集性、粘附性及TXA2、PGI2的影响。结果表明:正常家兔口服复方丹参方1.2、2.4、4.8g/kg及Aspirin 4.4mg/kg均显示出明显的抗ADP诱导的血小板聚集作用;明显抑制血小板粘附性;Aspirin明显降低正常家兔血浆TXA2水平(P<005);复方丹参方(4.8g/kg)明显升高血浆PGI2的水平(P<0.01);Aspirin及复方丹参方各剂量组对血浆TXA2/PGI2比值均无明显影响。提示复方丹参方抗正常家兔血小板粘聚作用与促进6-Ke-to-PGF1α的释放密切相关。

Abstract

Using semi-in vivo experiment method

we studied the effect of Fufangdanshwenfang on platelet aggregation and adhesion

TXA2 and PGI2 in normal rabbits.The results demonstrated that:given orally

both aspirin(4.4mg/kg) and Fufangdanshwenfang as different dosages(1.2

2.4

4.8g/kg) could markedly counteract ADP inducing platelet aggregation and inhibit platelet adhesion in normal rabbits.Moreover

aspirin could decrease the content of TXA2 in plasma

and Fufangdanshwenfang(4.8g/kg)could markedly raise the content of PGI2 in plasma.Both aspirin(4.4mg/kg)and Fufangdanshwenfang of different dosages had little effect on the proportion of TXA2 and PGI2 in plasma.The results suggested that the inhibition effect on platelet aggregation and adhesion of Fufangdanshwenfang was closely related to its promotion effect on the release of PGI2 in normal rabbits.

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