It has been shown that Tong Bu Qiang Gu Fang (TBQGF) has a good effect on the treatment of osteoporosis. Using the cell strain UMR 106

we observed the effects of several Chinese herbs

which were most important in the composition of TBQGF

on the proliferation of osteoblast-like cells in- vitro.- And we found that all of the Chinese herbs at appropriate concentrations could significantly promote the proliferation of osteoblasts. The high concentrations (500mg/L) of the Epimedii Hb and Ligustri Lucidi Fr had stronger effects on the proliferation of osteoblast-like cells than the low concentration (5mg/L). Astragali Membranace Rx showed a good effect at low concentration (5mg/L)

but no dose dependence relationship. Radix et Rhizoma of low concentration had no effect at all

the medium concentration (100mg/L) of it showed a significant promoting-proliferation effect

while the high concentration (1000mg/L) inhibited the proliferation of the cells. The results suggested that the herbs could promote the proliferation of osteoblast-like cells.