Experiment Studies on Dual-directional Regulation of Guizhitang for Rat Blood Pressure and Its Active Fractions of Guizhitang

QIN Cai-ling; LIU Ting; Zhang Yi; SUN Yu-ru; SUN You-fu; JIANG Ting-liang

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Experiment Studies on Dual-directional Regulation of Guizhitang for Rat Blood Pressure and Its Active Fractions of Guizhitang

更新时间：2024-01-04

- Experiment Studies on Dual-directional Regulation of Guizhitang for Rat Blood Pressure and Its Active Fractions of Guizhitang
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 7, Issue 4, Pages: 20-23(2001)
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- Published：2001
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QIN Cai-ling, LIU Ting, Zhang Yi, et al. Experiment Studies on Dual-directional Regulation of Guizhitang for Rat Blood Pressure and Its Active Fractions of Guizhitang[J]. Chinese journal of experimental traditional medical formulae, 2001, 7(4): 20-23.
DOI：

QIN Cai-ling, LIU Ting, Zhang Yi, et al. Experiment Studies on Dual-directional Regulation of Guizhitang for Rat Blood Pressure and Its Active Fractions of Guizhitang[J]. Chinese journal of experimental traditional medical formulae, 2001, 7(4): 20-23. DOI：

摘要

采用无损伤大鼠尾脉搏测压法

探讨了桂枝汤对大鼠血压的双向调节作用

并对其有效部位进行了筛选。结果表明:桂枝汤能明显降低自发性高血压大鼠(SHR)血压

能明显升高复方降压片致低血压大鼠血压

提示桂枝汤对大鼠血压具有明显双向调节作用;桂枝汤经化学分离提取所得A部分(Fr.A)和E部分(Fr.E)明显降低SHR血压

B部分(Fr.B)明显升高复方降压片致低血压大鼠血压;提示Fr.A、Fr.E和Fr.B为桂枝汤大鼠血压双向调节作用的有效部位。

Abstract

Experimental studies Guizhi Tang on rat blood pressure of by non-invasive method demonstrated that Guizhi Tang had significant blood pressure decreasing effect for SHR. Guizhitang had obvious blood pressure increasing effect to Tabellae Reserpini Compsitae-induced low blood pressure rat. Experiment demonstrated that Guizhi Tang had significant dual-directional regulation on blood pressure for rat. Active fractions A(Fr.A) and E (Fr.E)

isolated from Guizhi Tang had obvious blood pressure fall in SHR. Active fractions B(Fr.B)

isolated from Guizhi Tang had obvious blood pressure rise for Tabellae Reserpini Compsitae-induced low blood pressure rat; The results show that Fr.A and Fr.E and Fr.B are active fractions of Guizhi Tang with dual-directional regulation on rat blood pressure.

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Related Institution

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