The Protective Effect of Yi-Xin-Kang Capsule-containing Serum on the Activity of H-ATP Ase in Myocardial Mitochondria Injured by Oxygen Stress in Rats
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The Protective Effect of Yi-Xin-Kang Capsule-containing Serum on the Activity of H-ATP Ase in Myocardial Mitochondria Injured by Oxygen Stress in Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 7, Issue 4, Pages: 17-20(2001)
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Published:2001
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HAN Ling1, CHEN Ke-ji2. The Protective Effect of Yi-Xin-Kang Capsule-containing Serum on the Activity of H-ATP Ase in Myocardial Mitochondria Injured by Oxygen Stress in Rats[J]. Chinese journal of experimental traditional medical formulae, 2001, 7(4): 17-20.
DOI:
HAN Ling1, CHEN Ke-ji2. The Protective Effect of Yi-Xin-Kang Capsule-containing Serum on the Activity of H-ATP Ase in Myocardial Mitochondria Injured by Oxygen Stress in Rats[J]. Chinese journal of experimental traditional medical formulae, 2001, 7(4): 17-20.DOI:
The Protective Effect of Yi-Xin-Kang Capsule-containing Serum on the Activity of H-ATP Ase in Myocardial Mitochondria Injured by Oxygen Stress in Rats
Objective The protective effects of drug-containing serum of Yi-Xin-Kang capsule
a traditional Chinese medicinal prescription
and the individual drugs of the prescription
Danshen and Shanzha
on H+-ATP ase activity of rat myocardial mitochondria injured by oxygen stress were studied.Method Myocardial mitochondria were incubated with oxygen stress injury system(Fe2+/VitC)for 30 min
and then the activity of H+-ATPase was determined. Results Oxygen stress significantly decreased the activity of H+-ATPase of myocardial mitochondria. Treatment with the drug-containing serum of H303 or the individual drugs of Danshen and Shanzha significantly protected the activities of the enzyme. The significant protective effects were observed in lower doses(100 and 200mg/kg) of H303-treated groups and large doses (600mg/kg)of Dan-Shen or Shan-Zha-treated groups. Conclusion H303-containing serum protects the activity of H+-ATPase
a key-enzyme of myocardial mitochondria respiratory chain
injured by oxygen stress
in which Dan-Shen and Shan-Zha may contribute to the effect of H303.
The Protective Effect of Yi-Xin-Kang Capsule-containing Serum on Mitochondria Injury Induced by Oxygen Stress
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Related Author
HANG Ling1
MA Xiaona
HE Tiantian
HUO Chaoyue
SUN Xinhui
ZHANG Yuejian
ZHANG Wenjuan
LIN Taoxiu
Related Institution
Beijing University of Chinese Medicine Third Affiliated Hospital
Guizhou University of Traditional Chinese Medicine(TCM)
The Second Affiliated Hospital of Guizhou University of TCM