Effects of Qing Hua Capsule on Yong Excessive Hypertension Rats Induced by Three Factors

WANG Qin-mao1; LI Li1; ZHAO Yong2; CHENG Guang-liang1

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Effects of Qing Hua Capsule on Yong Excessive Hypertension Rats Induced by Three Factors

更新时间：2024-01-04

- Effects of Qing Hua Capsule on Yong Excessive Hypertension Rats Induced by Three Factors
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 8, Issue 3, Pages: 14-17(2002)
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- Published：2002
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WANG Qin-mao1, LI Li1, ZHAO Yong2, et al. Effects of Qing Hua Capsule on Yong Excessive Hypertension Rats Induced by Three Factors[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(3): 14-17.
DOI：

WANG Qin-mao1, LI Li1, ZHAO Yong2, et al. Effects of Qing Hua Capsule on Yong Excessive Hypertension Rats Induced by Three Factors[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(3): 14-17. DOI：

摘要

目的:观察清化胶囊对高血压肝阳上亢证的治疗作用。方法:用温里药(附子、肉桂、干姜)、麻黄碱及盐水制造大鼠高血压肝阳上亢证模型

观察清化胶囊对血压、心脏血流动力学的影响

测定血、尿内有关活性物质及心、肾脏器的病理学变化。结果:清化胶囊对模型鼠具有明显的降压作用

并降低SAP、DAP、LVSP、+dp/dtmax

降低血浆中cAMP、AngⅡ及TXB2水平

使6-k-PGF1a/TXB2比值上升

降低尿内3-甲氧肾上腺素(TMN)和NE含量

还有利尿作用。模型组和给药组对凝血和纤溶系统

以及心、肾脏的病理学均无明显影响。结论:清化胶囊对高血压肝阳上亢证大鼠有治疗作用。

Abstract

Yang excessive hypertension model of rat was induced by the mixture of three traditional Chinese medicines

ephedrine and normal saline water

respectively. Results showed Qing Hua Capsule could significantly decrease blood pressure of model rats. At the same time

it could also decrease levels of SAP

DAP

LVSP

+dp/dtmax

cAMP

Ang Ⅱ and TXB2 in blood plasma. It led to the rise of 6-k-PGF1α/TXB2 ratio. In addition

the content of TMN and NE in urine was decreased. It had no effects on coagulative and fibrinolytic system. It didn't significantly change the pathology of heart and kidney.

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