Effects of Xuefu Zhuyu Decoction on Endocrine Function of the Vascular Endothelial Cells Injured by Rabbit Stasis Syndrome Serum

Wang Qi; CHEN Yun-bo; LAI Shi-long; LIANG Wei-xiong; WEN Ze-huai

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Effects of Xuefu Zhuyu Decoction on Endocrine Function of the Vascular Endothelial Cells Injured by Rabbit Stasis Syndrome Serum

更新时间：2024-01-04

- Effects of Xuefu Zhuyu Decoction on Endocrine Function of the Vascular Endothelial Cells Injured by Rabbit Stasis Syndrome Serum
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 8, Issue 2, Pages: 12-14(2002)
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- Published：2002
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Wang Qi, CHEN Yun-bo, LAI Shi-long, et al. Effects of Xuefu Zhuyu Decoction on Endocrine Function of the Vascular Endothelial Cells Injured by Rabbit Stasis Syndrome Serum[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(2): 12-14.
DOI：

Wang Qi, CHEN Yun-bo, LAI Shi-long, et al. Effects of Xuefu Zhuyu Decoction on Endocrine Function of the Vascular Endothelial Cells Injured by Rabbit Stasis Syndrome Serum[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(2): 12-14. DOI：

摘要

目的:探讨血府逐瘀汤对用血瘀证兔模型血清损伤内皮细胞的保护作用

阐明该方调节血管内皮细胞内分泌功能的作用机理。方法:将正常组、血瘀模型组、血瘀+中药组和高脂血症组兔血清加入同批培养的正常兔主动脉内皮细胞中

作用24h后

观察细胞液中ET、NO的含量和t-PA、PAI及AT-Ⅲ活性的变化。结果:与正常血清组相比

血瘀血清组细胞液中的ET和NO含量都明显升高

PAI活性也明显升高

AT-Ⅲ活性则明显降低

t-PA活性虽有下降趋势

但无显著性意义;而血瘀+中药血清组细胞液中的ET和NO含量以及t-PA、PAI和AT-Ⅲ活性都未有明显改变。结论:血府逐瘀汤能调节血瘀证兔模型血清对内皮细胞ET/NO的释放平衡作用和降低其对抗凝、纤溶功能的影响

对内皮细胞起到一定的保护作用。

Abstract

To investigate the protective effects of Xuefu Zhuyu (XEZY) decoction on the vascular endothelial cells injured by rabbit blood stasis syndrome (BSS) serum and its effects of improvement on the endocrine dysfunction

we used the 4 different kinds of rabbit serum (normal

BSS with absorbed XFZY

hyperlipemic) to cultured rabbit vascular endothelial cells in vitro. The concentrations of endothelin (ET)

nitric oxide (NO) and the activity of tissue-type plasminogen activator (t-PA)

plasminogen activator inhibitor (PAI)

antithrombin Ⅲ(AT-Ⅲ)in cultured supernatant were detected at 24 hour

respectively. Results show the levels of ET

NO and the activity of PAI

except for t-PA

increased significantly in the BSS serum group

as compared with normal serum group. No significant differences of these vaso-active substance levels in cultured supernatant between normal and BSS with XFZY decoction. These results indicate that XFZY decoction can improve the endocrine dysfunction of the endothelial cells and protect cultured endothelial cells injured by rabbit BSS serum in vitro.

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