Effects of Danggui Buxue Decoction and the Decoction-contained Serum on Granulocyte-Macrophage Progenitor cell colony Forming Unit(GM-CFU)

ZHANG Ying-hua; WU Gui-lan; JIANG Ting-liang

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Effects of Danggui Buxue Decoction and the Decoction-contained Serum on Granulocyte-Macrophage Progenitor cell colony Forming Unit(GM-CFU)

更新时间：2024-01-04

- Effects of Danggui Buxue Decoction and the Decoction-contained Serum on Granulocyte-Macrophage Progenitor cell colony Forming Unit(GM-CFU)
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 5, Issue 6, Pages: 30-32(1999)
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- Published：1999
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ZHANG Ying-hua, WU Gui-lan, JIANG Ting-liang. Effects of Danggui Buxue Decoction and the Decoction-contained Serum on Granulocyte-Macrophage Progenitor cell colony Forming Unit(GM-CFU)[J]. Chinese journal of experimental traditional medical formulae, 1999, 5(6): 30-32.
DOI：

ZHANG Ying-hua, WU Gui-lan, JIANG Ting-liang. Effects of Danggui Buxue Decoction and the Decoction-contained Serum on Granulocyte-Macrophage Progenitor cell colony Forming Unit(GM-CFU)[J]. Chinese journal of experimental traditional medical formulae, 1999, 5(6): 30-32. DOI：

摘要

当归补血汤煎液(Ⅰ)对小鼠粒系—巨系造血祖细胞(CFU-GM)的生长有抑制作用

剂量越大

抑制作用越强.当归补血汤口饲小鼠后的含药血清(Ⅱ)对CFU-GM的生长有明显的激活作用

剂量越大

CFU-GM集落生长的越多.药在相同含药血清浓度下

从时—效关系求出当归补血汤的药效动力学参数

Ke=0.3961/h

T1/2(Ke)=2.1602h

Ka=1.3422/h

T1/2(Ka)=1.6057h

Tp=1.5978h

Td=14.8019h.

Abstract

Danggui buxue decoction could inhibit growth of Granulocyte-Macrophage Progenitor cell colony forming unit(GM-CFU)

and the more dose was

the less GM-CFU was.But the decoction-contained serum could promote growth of GM-CFU

and the more dose was

the more GM-CFU was.On the basis of the time-effect cure gained from the decoction-contained serum

pharmacokinetics parameters were as follows:Ke

T1/2(ke)

T1/2(ka)

Tp and Td was 0.3961/h

2.1602h

1.3422/h

1.6057h

1.5978h and 14.8019h

respectively.

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Related Institution

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