The Purgative Effect and Pharmacokinetics Rhubarb's Combined Anthraquinone
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The Purgative Effect and Pharmacokinetics Rhubarb's Combined Anthraquinone
Chinese Journal of Experimental Traditional Medical FormulaeVol. 5, Issue 6, Pages: 53-55(1999)
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Published:1999
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WEI Feng-ling, CHANG Ming, YUAN Guo-qiang. The Purgative Effect and Pharmacokinetics Rhubarb's Combined Anthraquinone[J]. Chinese journal of experimental traditional medical formulae, 1999, 5(6): 53-55.
DOI:
WEI Feng-ling, CHANG Ming, YUAN Guo-qiang. The Purgative Effect and Pharmacokinetics Rhubarb's Combined Anthraquinone[J]. Chinese journal of experimental traditional medical formulae, 1999, 5(6): 53-55.DOI:
The Purgative Effect and Pharmacokinetics Rhubarb's Combined Anthraquinone
The effects of Rhubarb combined anthraquinone on promoting intestinal peristalsis
dose response relationship and pharmacokinetics were investigated in mice.The time of defecation and the appearance of stool were recorded by using the charcoal powder method.The results indicated that oral administration of combined anthraquinone significantly promoted the peristalsis and reduced diarrhea in mice.The reference dose of promoting peristalsis was 18.22~25.79mg/kg
and the dose of reducing diarrhea was 150.48mg/kg.Both results of dose response and time response were linear relationship.The t01/2 was 5.10 hours.