Determination of Apparent Pharmacokinetic Parameters of Dinggongteng Injection with Drug Accumulation Method
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Determination of Apparent Pharmacokinetic Parameters of Dinggongteng Injection with Drug Accumulation Method
Chinese Journal of Experimental Traditional Medical FormulaeVol. 5, Issue 6, Pages: 50-52(1999)
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Published:1999
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WEI Min, Li Rui, ZHOU Li-ling. Determination of Apparent Pharmacokinetic Parameters of Dinggongteng Injection with Drug Accumulation Method[J]. Chinese journal of experimental traditional medical formulae, 1999, 5(6): 50-52.
DOI:
WEI Min, Li Rui, ZHOU Li-ling. Determination of Apparent Pharmacokinetic Parameters of Dinggongteng Injection with Drug Accumulation Method[J]. Chinese journal of experimental traditional medical formulae, 1999, 5(6): 50-52.DOI:
Determination of Apparent Pharmacokinetic Parameters of Dinggongteng Injection with Drug Accumulation Method
Apparent pharmacokinetic parameters of Dinggongteng Injection were determined with drug accumulation method.The results indicated that one compartment open model was the best to describe dynamic change of this injection in mice.The apparent pharmacokinetic parameters are as follows:K=0.033h-1
T1/2=20.961h
Cl=0.066kg/(kg.h).The results can provide referential basis for the use of this injection in clinical practice.
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