Investigation of Fuzheng Huayu Decoction on Coordination Effect of Anti-fibrosis of Liver with Serum Pharmacology

WANG Xiao-ling1; LIU Ping2; LIU cheng-hai2; LIU cheng2; GU Hong-tu2

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Investigation of Fuzheng Huayu Decoction on Coordination Effect of Anti-fibrosis of Liver with Serum Pharmacology

更新时间：2024-01-04

- Investigation of Fuzheng Huayu Decoction on Coordination Effect of Anti-fibrosis of Liver with Serum Pharmacology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 5, Issue 6, Pages: 22-25(1999)
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- Published：1999
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WANG Xiao-ling1, LIU Ping2, LIU cheng-hai2, et al. Investigation of Fuzheng Huayu Decoction on Coordination Effect of Anti-fibrosis of Liver with Serum Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 1999, 5(6): 22-25.
DOI：

WANG Xiao-ling1, LIU Ping2, LIU cheng-hai2, et al. Investigation of Fuzheng Huayu Decoction on Coordination Effect of Anti-fibrosis of Liver with Serum Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 1999, 5(6): 22-25. DOI：

摘要

将扶正化瘀方分为扶正组、化瘀组、虫草组、丹参组及丹参加虫草组

灌胃给药分离药物血清

观察各药物血清对大鼠肝星状细胞增殖、活化、型胶原和TGFβ1蛋白及其mRNA表达的影响.各组药物血清均可抑制星状细胞的增殖和活化

其中化瘀组效果最明显;各组药物血清均可抑制星状细胞型胶原mRNA及其蛋白的生成

以扶正组效果最佳;各组药物血清星状细胞TGFβ1mRNA及其蛋白生成均有明显的降低

以虫草组作用最强.

Abstract

Fuzheng Huayu(FZHY) decoction was divided into five subgroups: Fuzheng group

Huayu group

Cordyceps group

Salvia Mitiorihizae group and Cordyceps plus Salvia Mitiorihizae group.Five types of serum containing correspondent drugs were collected from rats

respectively.The results showed that the five types of serum could inhibit hepatic stellate cells(HSC)and the effect of the serum containing Huayu was the best.The five types of serum could also inhibit mRNA expression and protein synthesis of type Ⅰ collagen in HSC

and the effect of the serum containing Fuzheng was the best.The five types of serum could also inhibit mRNA expression and protein synthesis of transforming growth factor β1 in HSC

and the effect of the serum containing Cordyceps was the best.

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