Objective: To prepare dl-tetrahydropalmatine flexible liposomes and study its transdermal absorption effect. Method: The flexible liposomes was prepared by film dispersion method

modified Franz diffusion cell method was used to study its transdermal absorption effect. Result: Particle size of the flexible liposomes was (112.3±59.2) nm with a normal distribution basically

entrapment efficiency was 82.7%.Cumulative permeation amount of dl-tetrahydropalmatine flexible liposomes was 2 121 μg within 12 h

which was significantly higher than that of tincture (1 153 μg).The retention rate in skin was 53.9%

which was obviously higher than that of tincture(11.2%). Conclusion: Transdermal absorption effect of these prepared dl-tetrahydropalmatine flexible liposomes was superior than that of tincture.