Objective: To optimize extraction technology of Qixue Shuangbu oral liquid. Method: Alcohol and water dual extraction method was adopted

with extraction amount of astragaloside IV as index

effects of extraction time

the concentration of ethanol

the amount of ethanol and extraction times on alcohol extraction technology was investigated by orthogonal test;With extraction ratio of peoniflorin and icariin as indicators

extraction time

extraction times and the amount water as factors

water extraction technology was optimized by orthogonal test. Result: Optimum extraction technology conditions were as follows:Astragalus membranaceus and Angelica sinensis were extracted twice with 8 times the amount of 70% ethanol by 1.5 h per time;Then the gruffs and else prescription drugs were reflux extracted 3 times with 9 the amount of water by two hours every time. Conclusion: This optimized extraction technology was scientific

reasonable

stable and feasible.