ZHU Shuang-yan, YIN Rong-li, CUI Ming-quan, et al. Prescription Optimization and Quality Evaluation of Andrographolide Self-microemulsion Preparation[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 55-59.
DOI:
ZHU Shuang-yan, YIN Rong-li, CUI Ming-quan, et al. Prescription Optimization and Quality Evaluation of Andrographolide Self-microemulsion Preparation[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 55-59. DOI: 10.11653/syfj2013080055.
Prescription Optimization and Quality Evaluation of Andrographolide Self-microemulsion Preparation
Objective: To optimize formulation of andrographolide self-microemulsifying preparation and evaluate its quality. Method: Type and dosage range of excipients was selected by solubility test
prescription compatibility comparison test and drawing ternary phase diagram
with appearance
particle size
zeta potential
self-emulsifying time and preparation stability of the formed emulsion as indexes
central composite design-response surface methodology was used to optimize self-microemulsion prescription and evaluate its quality. Result: Optimum prescription of this preparation was as following:mtween-80:methyl oleate:mglycerol=50:26:26
particle size 39.5 nm
zeta potential -15.18 mV
self-emulsifying time 40.53 s. Conclusion: These acquired androgra-pholide self-microemulsion preparation was clear and transparent with good physical stability.
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Related Author
Hui-zhen QIN
Si LIN
Ling-yu DENG
Feng-feng XIE
Miao ZHANG
Hua ZHU
Long CHEN
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Related Institution
Guangxi University of Chinese Medicine
Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine,Guangxi University of Chinese Medicine
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