WU Hong-mei, XU Feng, LIU Li-mei, et al. Investigation of UPLC Fingerprint for Kangfuxin Liquid[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 59-62.
DOI:
WU Hong-mei, XU Feng, LIU Li-mei, et al. Investigation of UPLC Fingerprint for Kangfuxin Liquid[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 59-62. DOI: 10.11653/syfj2013080059.
Investigation of UPLC Fingerprint for Kangfuxin Liquid
Objective: To establish an UPLC characteristic chromatographic profile analysis method for Kangfuxin liquid
and provide basis for rapid evaluating quality of it. Method: Taking ZORBAX RRHD Eclipse plus C18 column (2.1 mm×100 mm
1.8 μm)
with methanol-0.05% acetic acid solution as mobile phase
detection wavelength 256 nm. Fifteen batches of Kangfuxin liquid from different manufacturers were investigated
fingerprint was analysed by 2004A edition of chromatographic fingerprint similarity evaluation system and cluster analysis software. Result: There were 10 common peaks in 11 batches of Kangfuxin liquid from Kelun pharmaceutical and 3 batches from Haoyisheng Panxi pharmaceutical
the peaks similarity was more than 0.990;However
only 8 common peaks in these productions from Inner Mongolia Jingxin pharmaceutical
the similarity was lower than 0.900 by comparing with the control fingerprint.Five common peaks were identified in the fingerprint. Conclusion: This established method was rapid and effective
it could be useful for quality evaluation of Kangfuxin liquid.
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Related Author
LIU Jing
SU Jian-chun
GAN Lin-jian
YIN Rong-li
LI Hua
Yan MENG
Wu-yi LI
Jia-ming SHAN
Related Institution
Key Laboratory of Modern Preparation of Traditional Chinese Medicine (TCM),Ministry of Education,Jiangxi University of TCM
Kunming Municipal Hospital of Traditional Chinese Medicine
Yunnan Provincial Key Laboratory of Research on External Drug Delivery System and Preparation Technology in University,Yunnan University of Chinese Medicine
College of Pharmacy and Chemistry, Key Laboratory of Universities in Yunnan Province on Development of Genuine Medicinal Materials Resources in Western Yunnan, Dali University