Optimization of Water Extraction and Alcohol Precipitation Technology of Kubai Fuyan Suppositories

YAO Lin; SUN Yan; GAO Fei; WANG Wei-ming

doi:10.11653/syfj2013080066

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Optimization of Water Extraction and Alcohol Precipitation Technology of Kubai Fuyan Suppositories

更新时间：2024-01-04

- Optimization of Water Extraction and Alcohol Precipitation Technology of Kubai Fuyan Suppositories
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 8, Pages: 66-69(2013)
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- DOI：10.11653/syfj2013080066
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- Published：2013
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YAO Lin, SUN Yan, GAO Fei, et al. Optimization of Water Extraction and Alcohol Precipitation Technology of Kubai Fuyan Suppositories[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 66-69.
DOI：

YAO Lin, SUN Yan, GAO Fei, et al. Optimization of Water Extraction and Alcohol Precipitation Technology of Kubai Fuyan Suppositories[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 66-69. DOI： 10.11653/syfj2013080066.

摘要

目的: 优选苦柏妇炎栓的提取、醇沉工艺。方法: 采用水提醇沉法

以苦参碱、盐酸小檗碱、蛇床子素质量为指标

通过正交试验考察料液比、提取次数及提取时间对苦柏妇炎栓水提取工艺的影响;以苦参碱、盐酸小檗碱、蛇床子素质量的综合评分为指标

通过正交试验考察浓缩液相对密度、醇沉浓度及放置时间对醇沉工艺的影响。结果: 优选的提取工艺为加12倍量水提取3次

每次2 h;优选的醇沉工艺为提取液浓缩至相对密度1.18(25 ℃)

醇沉浓度60%

放置12 h。结论: 优选的工艺稳定可行

为苦柏妇炎栓的临床应用提供实验依据。

Abstract

Objective: To optimize water extraction and alcohol precipitation technology of Kubai Fuyan suppositories. Method: Water extraction and alcohol precipitation method was adopted

with the quality of matrine

berberine and osthole as indexes

effects of liquid-solid ratio

extraction times and time on water extraction technology was investigated by orthogonal test;With composite score of the quality of matrine

berberine and osthole as index

the relatively density of concentrated liquid

the concentration of alcohol precipitation and storage time were chosen as factors

alcohol precipitation technology was optimized by orthogonal test. Result: Optimum extraction process was as following:extracted 3 times with 12 times the amount of water

2 hours each time;Optimized alcohol precipitation technology was:the relative density of concentrated liquid 1.18 (25 ℃)

the concentration of alcohol precipitation 60%

placed 12 hours. Conclusion: These optimized technologies was stable

reasonable and feasible

them could provide experimental basis for clinical application of Kubai Fuyan suppositories.

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Related Institution

Jilin Natural Pharmaceutical Research and Development Co.Ltd.

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