Study on Preventive Effect of Prescription for Tonifying Kidney During Embryonic Period on IGT and Insulin Resistance,Leptin Resistance

XU Kai-xia; WANG Yong-hui; YANG Xiang-zhu; NIU Xin; FENG Qian-jin

doi:10.11653/syfj2013080167

您当前的位置：

首页 >

文章列表页 >

Study on Preventive Effect of Prescription for Tonifying Kidney During Embryonic Period on IGT and Insulin Resistance,Leptin Resistance

更新时间：2024-01-04

- Study on Preventive Effect of Prescription for Tonifying Kidney During Embryonic Period on IGT and Insulin Resistance,Leptin Resistance
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 8, Pages: 167-171(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013080167
  CLC：
- Published：2013
- 稿件说明：
移动端阅览
XU Kai-xia, WANG Yong-hui, YANG Xiang-zhu, et al. Study on Preventive Effect of Prescription for Tonifying Kidney During Embryonic Period on IGT and Insulin Resistance,Leptin Resistance[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 167-171.
DOI：

XU Kai-xia, WANG Yong-hui, YANG Xiang-zhu, et al. Study on Preventive Effect of Prescription for Tonifying Kidney During Embryonic Period on IGT and Insulin Resistance,Leptin Resistance[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 167-171. DOI： 10.11653/syfj2013080167.

摘要

目的: 通过大鼠胚胎发育期予补肾方干预

以研究中医补肾方在胚胎发育期干预能否预防高脂饮食诱发的子代成年大鼠糖耐量低减(IGT)及其对胰岛素、瘦素的影响。方法: 将孕鼠分为正常对照组、模型组、左归丸组、右归丸组、八珍汤组

在孕1～19 d

各用药组分别以左归丸、右归丸、八珍汤灌胃(ig

20 g·kg-1

20 mL·kg-1)

正常对照组和模型组以生理盐水灌胃。除正常对照组外

其余各组子鼠均于6周龄开始高脂饲料喂养

12周后测各组子鼠空腹血糖(FBG)、糖负荷后2 h血糖(2hBG)、血清空腹胰岛素、瘦素。结果: 与模型组比较

左归丸组2hBG明显降低(P<0.05);八珍汤组和右归丸组2hBG无明显降低。左归丸组、右归丸组、八珍汤组胰岛素抵抗指数(HOMA-IR)均较模型组显著降低(P<0.01

P<0.01

P<0.05)。左归丸组和右归丸组血清瘦素显著低于模型组(P<0.01

P<0.01);而八珍汤组血清瘦素水平与模型组相比无显著性差异。结论: 左归丸与右归丸胚胎期干预都可对抗高脂饮食引发子代成年大鼠胰岛素抵抗、瘦素抵抗

但对IGT的预防作用以左归丸为优。八珍汤组对抗胰岛素抵抗、瘦素抵抗作用相对弱

也未能预防高脂饮食引起的子鼠IGT的发生。

Abstract

Objective: This project aimed to find if prescription for tonifying kidney fed during embryonic development can prevent impaired glucose tolerance(IGT) caused by feeding high fat diet and its influence on insulin and leptin. Method: The pregnant rats were randomly divided into 5 groups. The normal control group and model group were fed by normal saline on the 1st day

20 mL·kg-1.In other 3 experiment groups

the pregnant rats were fed respectively with Zuogui Wan (ZGW

a prescription for reinforcing kidney Yin) or Yougui Wan(YGW

a prescription for reinforcing kidney Yang)or Bazhen decoction (BZD

a prescription for supplementing Qi and Blood)

20 g·kg-1

20 mL·kg-1

at the same time. After birth

the offsping rats in the other four groups except the control group were fed with high fat diet in 6th week. After 12 weeks of high fat diet

the fasting blood glucose(FBG)

2 h blood glucose(2 hBG)

fasting serum insulin and serum leptin concentrations were measured. Result: 2 hBG of ZGW group was significant lower than 2 hBG of model group(P<0.05);2 hBG of ZGW group and YGW group was not significantly different from model group.HOMA-IR of ZGW group

YGW group and BZD group was significantly lower than HOMA-IR of model group(P<0.01

P<0.01

P<0.05).Leptin of ZGW group and YGW group was significantly lower than leptin of model group (P<0.01

P<0.01). Leptin of BZD group was not significantly different from model group. Conclusion: ZGW and YGW during embryonic development can all withstand the adverse changes of serum insulin

and ZGW can prevent IGT caused by high fat diet

but YGW can not.BZD during embryonic development can also withstand the adverse changes of serum insulin and can not withstand the adverse changes of serum leptin

which is not as good as ZGW and YGW

and can not prevent IGT caused by high fat diet.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effects of Different Medicine Compatibility of Modified Wendan Tang on Nutritional Obesity in Rats

Youguiwan Reduces Airway Inflammation in COPD Rats with Syndrome of Kidney-Yang Deficiency by Inhibiting Leptin/JAK2/STAT3 Signaling Pathway

Mechanism of Bushen Huatan Prescription in Regulation of Osteogenesis and Adipogenic Differentiation and Improvement of Postmenopausal Bone Loss in Ovariectomized Rats with Osteoporosis

Effect of Shenqi Compound on Islet β-cell Function in Type 2 Diabetic GK Rats

Effect of Wenshen Zhuyang Tiaozhou Method on Sex Hormones, Insulin and Ovulation in PCOS Patients with Kidney-Yang Deficiency Syndrome Based on PI3K/Akt Signaling Pathway

Related Author

YAO Feng-yun

WANG Ya-le

Liu Cheng

WANG Xiao-fang

LIU Chun-hua

WANG Bing-zhi

ZHENG Lan

LUO Zeyuan

Related Institution

College of Basic Medical Sciences， Hubei University of Chinese Medicine

Laboratory Animal Center， Hubei University of Chinese Medicine

College of Traditional Chinese Medicine， Hubei University of Chinese Medicine

Hubei Shizhen Laboratory

First Clinical College，Hubei University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰