Protective Effect of Saponins from Bupleurum Chinense on Ethanol-induced Gastric Lesion

WANG Shuai; BAO Yong-rui; MENG Xian-sheng; YANG Xin-xin

doi:10.11653/syfj2013080191

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Protective Effect of Saponins from Bupleurum Chinense on Ethanol-induced Gastric Lesion

更新时间：2024-01-04

- Protective Effect of Saponins from Bupleurum Chinense on Ethanol-induced Gastric Lesion
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 8, Pages: 191-194(2013)
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- DOI：10.11653/syfj2013080191
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- Published：2013
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WANG Shuai, BAO Yong-rui, MENG Xian-sheng, et al. Protective Effect of Saponins from Bupleurum Chinense on Ethanol-induced Gastric Lesion[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 191-194.
DOI：

WANG Shuai, BAO Yong-rui, MENG Xian-sheng, et al. Protective Effect of Saponins from Bupleurum Chinense on Ethanol-induced Gastric Lesion[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 191-194. DOI： 10.11653/syfj2013080191.

摘要

目的: 研究柴胡皂苷对大鼠无水乙醇致胃黏膜损伤的保护作用及其机制。方法: 将大鼠分成对照组、模型组、柴胡皂苷组(0.047 g·kg-1)和奥美拉唑组(0.012 g·kg-1)。给药2周后

采用无水乙醇灌胃建立大鼠胃黏膜损伤模型

以溃疡指数、病理损伤程度评价柴胡皂苷对胃黏膜的保护作用;采用酶联免疫法

测定无水乙醇致胃黏膜损伤大鼠血清中前列腺素E2(PGE2)、超氧化物歧化酶(SOD)、丙二醛(MDA)

探讨柴胡皂苷的胃黏膜保护作用机制。结果: 柴胡皂苷给药组溃疡指数明显低于模型组(P<0.01);组织病理学积分判定结果

柴胡皂苷组与模型组比较有统计学差异(P<0.05);血清PGE2明显高于模型组(P<0.01)

SOD明显高于模型组(P<0.01)

MDA明显低于模型组(P<0.01)。结论: 柴胡皂苷具有明显的胃黏膜损伤保护作用

可能与抑制胃酸分泌及抗自由基损伤有关。

Abstract

Objective: This study was aimed at investigating the effects and mechanism of saponins from bupleurum chinense on ethanol-induced gastric mucosal injury in rats. Method: The rats were divided into control group

model group

bupleurum chinense saponins group (0.047 g·kg-1) and omeprazole group (0.012 g·kg-1) respectively. After two weeks treatment

the experimental gastric damages were established by intragastric ethanol.The protective effects of bupleurum chinense saponins were evaluated by calculating lesion indices and observing pathological changes; meanwhile

the contents prostaglandin E2(PGE2)

superoxide dismutase(SOD) and malondialdehyde(MDA) in serum were measured with euzymelinked immunosorbent assay to determine the protecting mechanism. Result: The lesion indices of bupleurum chinense saponins group were significantly lower than the model group(P<0.01). There was no damage was detected in most of rats in treatment group except for small damages in a few rats

and the integral between bupleurum chinense saponins and treatment groups showed statistical differences(P<0.05). The contents of PGE2

SOD in serum of bupleurum chinense saponins group were higher while MDA was lower than the model group(all P<0.01). Conclusion: bupleurum chinense saponins show obvious protective effect on gastric mucosa damage

and its mechanism may be through restraining the gastric mucosa acid secretion and counteracting the injury of free radical.

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