Effect of Total Organic Acid of  on Active Capacity of Isolated Rat Uterine Smooth Muscle

ZHAO Pan; TONG Ji-ming; LIU Yu-ling; SONG Su-ying

doi:10.11653/syfj2013080202

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Effect of Total Organic Acid of on Active Capacity of Isolated Rat Uterine Smooth Muscle

更新时间：2024-01-04

- Effect of Total Organic Acid of on Active Capacity of Isolated Rat Uterine Smooth Muscle
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 8, Pages: 202-205(2013)
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- DOI：10.11653/syfj2013080202
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- Published：2013
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ZHAO Pan, TONG Ji-ming, LIU Yu-ling, et al. Effect of Total Organic Acid of on Active Capacity of Isolated Rat Uterine Smooth Muscle [J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 202-205.
DOI：

ZHAO Pan, TONG Ji-ming, LIU Yu-ling, et al. Effect of Total Organic Acid of on Active Capacity of Isolated Rat Uterine Smooth Muscle [J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 202-205. DOI： 10.11653/syfj2013080202.

摘要

目的: 观察赤雹果总有机酸(FTDBP)对大鼠离体子宫平滑肌活力的影响。方法: 选用8周龄Wistar雌性未孕大鼠

以子宫平滑肌的收缩频率、收缩幅度指标

计算子宫平滑肌活力及FTDBP的半数抑制浓度(IC50)。以盐酸普萘洛尔、盐酸苯海拉明、盐酸雷尼替丁、硫酸阿托品为阻断剂

观察FTDBP对子宫平滑肌作用与β

M受体的关系

探讨FTDBP对子宫平滑肌的作用机制。结果: 与模型组比较

FTDBP剂量组(0.032

0.064

0.128 g·L-1)和元胡止痛片组对缩宫素所致大鼠离体子宫平滑肌的收缩频率、收缩幅度和活力均有明显的抑制作用(P<0.05或P<0.01)

IC50为0.100 24 g·L-1;与模型组比较

硫酸阿托品组大鼠子宫平滑肌的收缩频率、幅度和活力差异无统计学意义。结论: FTDBP对大鼠子宫平滑肌活力有明显的抑制作用

其作用是通过抑制M受体实现的

与H1

β受体无关。

Abstract

Objective: To explore the effects of the total organic acid of Thladiantha dubia (FTDBP) on activity of isolated rat uterus smooth muscle in vitro. Method: The effect of the FTDBP on activity of the isolated rat uterus smooth muscle of non-pregnant rats eight weeks old was recorded by Maclab/4e four channels physiological recorder. Four antagonists

propranolol hydrochloride tablets (3.4×10-7mol·L-1)

diphenhydramine hydrochloride tablets (2×10-6 mol·L-1)

ranitidine hydrochloride tablets (2×10-5 mol·L-1) and atropine sulfate tablets (2×10-5 mol·L-1) were used to study their mechanism respectively. Result: Compare with model group

the FTDBP markedly inhibited the tension

frequency and activity of uterus of rat in vitro.And the IC50 of FTDBP was 0.100 24 g·L-1. Conclusion: The effect of FTDBP on activity of uterine smooth muscle in rats is mainly associated with M receptor but not H1 receptor

H2 receptor or β receptor.

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