Effects of Ethanol Extraction from Cassiae Semen on Leptin and NPY in Hyperlipidemia Rats

GAO Li; ZHOU Wen-jing; MA Yan-miao; WANG Yong-hui

doi:10.11653/syfj2013080235

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Effects of Ethanol Extraction from Cassiae Semen on Leptin and NPY in Hyperlipidemia Rats

更新时间：2024-01-04

- Effects of Ethanol Extraction from Cassiae Semen on Leptin and NPY in Hyperlipidemia Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 8, Pages: 235-238(2013)
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- DOI：10.11653/syfj2013080235
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- Published：2013
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GAO Li, ZHOU Wen-jing, MA Yan-miao, et al. Effects of Ethanol Extraction from Cassiae Semen on Leptin and NPY in Hyperlipidemia Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 235-238.
DOI：

GAO Li, ZHOU Wen-jing, MA Yan-miao, et al. Effects of Ethanol Extraction from Cassiae Semen on Leptin and NPY in Hyperlipidemia Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 235-238. DOI： 10.11653/syfj2013080235.

摘要

目的: 观察决明子乙醇提取物对实验性高脂血症模型大鼠血脂、血糖、瘦素(leptin)及神经肽Y(NPY)的影响

探讨决明子治疗高脂血症的机制。方法: 采用高脂饲料饲喂的方法建立高脂血症大鼠模型。造模成功后

随机分为5组

模型组

阳性对照组(血脂康

0.15 g·kg-1)

决明子低、中、高剂量组(4

16 g·kg-1)

各组均按10 mL·kg-1体积ig给予相应药物

并设正常对照组

连续ig 4周。给药期间继续饲喂高脂饲料。末次给药后

采血

全自动生化仪测定大鼠血清总胆固醇(TC)、甘油三醋(TG)、低密度脂蛋白-胆固醇(LDL-C)、高密度脂蛋白-胆固醇(HDL-C)、葡萄糖(Glu)的含量

ELISA法测定血清中leptin

NPY的含量。结果: 与模型组比较

决明子乙醇提取物高、中剂量组能明显降低大鼠血清中TC

LDL-C

Glu的含量

显著升高HDL-C的含量(P<0.01)。高脂血症模型大鼠leptin

NPY水平明显升高

决明子乙醇提取物高、中剂量可显著降低大鼠leptin

NPY水平(P<0.01)。结论: 决明子乙醇提取物可有效改善高脂血症模型大鼠的血糖及血脂水平

其可能通过调节leptin-NPY系统来实现。

Abstract

Objective: To observe effects of ethanol extraction from Cassiae Semen on leptin and neuropeptide Y(NPY) in hyperlipidemia rats. Method: The rat hyperlipidemia model was established by feeding high calorie-diet. After modeling

the selected rats were randomly divided into six groups: normal control group

model group

positive control group

low dose group

medium dose group and high dose group. Positive control group was administrated Xuezhikang capsule at dose of 0.15 g·kg-1. Low dose group

medium dose group and high dose group were administrated at different concentrations of ethanol extraction of Cassiae Semen

which was respectively 4

16 g·kg-1. All groups were applied by intragastric administration for 4 weeks. Except normal control group

the remains were fed with high calorie-diet. After the last administration

the serum content of total cholesterol (TC)

triglyceride(TG)

low-density lipoprotein-cholesterol(LDL-C)

high-density lipoprotein-cholesterol(HDL-C) and glucose(Glu) were detected by automated chemistry analyzer. And the content of leptin and NPY was determined by ELISA. Result: The content of TC

LDL-C and Glu was decreased

and the content of HDL-C was increased in medium dose group and high dose group of ethanol extraction of Cassiae Semen

compared with model group(P<0.01). At the same time

the content of leptin and NPY was decreased in medium dose group and high dose group(P<0.01). Conclusion: Ethanol extraction of Cassiae Semen can regulate the metabolic process of blood lipids and blood glucose levels of hyperlipidemia model rats

which might be contributed to its effect on leptin-hypothalamic neuropeptide Y chain.

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