Objective: To observe the effect of Mongolian medicine GEI Wang-9 on acute liver failure induced by carbon tetrachloride CCl4. Method: methods 30% carbon tetrachloride was used to induce model of acute liver failure. After 24 h

indexes alanine aminotransferase(ALT)

aspartate aminotransferase(AST)

nitric oxide(NO)

active of nitric oxide composite enzyme (NOS) of serum and liver index and pepsin in the stomach homogenate were detected in normal group

model group

Mongolian medicine GEI Wang-9 low

middle

high dose groups(1.3

2.6

3.9 g·kg-1)

respectively. Result: In the model group

compared with normal group

serum AST

ALT extremely increased significantly (all P<0.01); NO

nitric oxide composite enzyme and liver indexall increased significantly (P<0.05). Compared with model group

GEI Wang-9 low doses decreased significantly the serum NO

nitric oxide composite enzymeall (P<0.05). GEI Wang-9

middle doses decreased significantly the serum AST

ALT(P<0.01

P<0.05

respectively); and NO

nitric oxide composite enzyme and liver index reduced significantly (P<0.05). High doses reduced significantly the serum AST

ALT(P<0.01

P<0.05

respectively); NO

nitric oxide composite enzyme and liver index reduced significantly (P<0.05). Conclusion: Mongolian medicine GEI Wang-9 has protective actions on acute liver failure induced by carbon tetrachloride.