TANG Li-ping, WEI Yi. Effect of Modified Guizhi Fuling Decoction on Serum Leptin Levels in Patients with Polycystic Ovarian Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 293-295.
DOI:
TANG Li-ping, WEI Yi. Effect of Modified Guizhi Fuling Decoction on Serum Leptin Levels in Patients with Polycystic Ovarian Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 293-295. DOI: 10.11653/syfj2013080293.
Effect of Modified Guizhi Fuling Decoction on Serum Leptin Levels in Patients with Polycystic Ovarian Syndrome
Objective: To investigate the effect of modified Guizhi Fuling decoction combined swith routine western medicine therapy on polycystic ovarian syndrome (PCOS) and leptin (LP) in patients. Method: Ninety-four patients with PCOS were randomly divided into observation group (n=49) and control group (n=45). Patients in control group orally took ethinylestradiol and cyproterone acetate tablet
1 tablet daily; metformin hydrochloride tablet
0.5 g tid
from the third day of menstruation. There was a discontinuation at menstruation. Observation group was given modified Guizhi Fuling decoction
1 dose daily
on the basis of control group. The treatment course of the two groups lasted 3 menstruation cycles. The patients' body mass index (BMI)
fasting glucose and fasting insulin were recorded. Five indexes of endocrine were observed by radioimmunoassay. Serum LP was tested by enzyme linked immunosorbent assay. Result: After treatment
follicle stimulating hormone (FSH)
luteinizing hormone (LH)
estrodiol 2 (E2)
testosterone (T) and prolactin (PRL) in the two groups were decreased than those before treatment. LH
E2 and T in observation group were lower than those in the control group (P<0.05); BMI in the two groups were decreased compared with those before treatment
and BMI in observation group were lower than that in control group (P<0.05); Serum LP in observation group was (9.68±2.59) μg·L-1
which was significantly lower than (10.75±2.67) μg·L-1 in control group (P<0.05). Conclusion: Modified Guizhi Fuling decoction can improve insulin resistance by significantly decreasing LH
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