Objective: To observe the effect of treating chronic urticarial (CU) based on spleen differentiation. Method: This prospective

noncomparative interventional case series observed 72 patients with CU which were divided into three groups based on spleen differentiation: the group with deficiency of spleen (group 1) was given modified Shenling Baizhu San

the group with Qi deficiency of spleen and lungs (group 2) was given modified Yupingfeng San

and the group with deficiency of heart and spleen syndrome (group 3) was given modified Guipi Tang. Items such as changes in clinical symptoms and signs

recurrence after treatment

and side effects were examined. Result: After the treatment

satisfactory effects showed that total efficacy rate of group 1 was 92.31%

group 2 was 91.67%

group 3 was 90.91%. No significant deviation between the groups was found. And after 2 month follow-up for the cured patients

2 patients in group 1 showed relapse

and 1 in group 2

2 in group 3.So

no significant deviation was found for relapse. There were no side effect or abnormal phenomenon was found on the items of blood routine

urine routine

liver function and kidney function as well. Conclusion: Treating chronic urticarial based on spleen differentiation is a safe and effective therapeutic procedure

which is worth the further study and clinical application.