Effect of Shenkang Injection as an Adjunctive Treatment on Early Diabetic Nephropathy and on Patient's Oxidative Stress

WANG Ai-yuan; FANG Hui; WANG Yu; TIAN Luo-bing; ZHANG Kun; TANG Wen-Jun; PENG Peng; DAI Li-zhi; YANG Yue

doi:10.11653/syfj2013080308

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Effect of Shenkang Injection as an Adjunctive Treatment on Early Diabetic Nephropathy and on Patient's Oxidative Stress

更新时间：2024-01-04

- Effect of Shenkang Injection as an Adjunctive Treatment on Early Diabetic Nephropathy and on Patient's Oxidative Stress
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 8, Pages: 308-310(2013)
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- DOI：10.11653/syfj2013080308
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- Published：2013
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WANG Ai-yuan, FANG Hui, WANG Yu, et al. Effect of Shenkang Injection as an Adjunctive Treatment on Early Diabetic Nephropathy and on Patient's Oxidative Stress[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 308-310.
DOI：

WANG Ai-yuan, FANG Hui, WANG Yu, et al. Effect of Shenkang Injection as an Adjunctive Treatment on Early Diabetic Nephropathy and on Patient's Oxidative Stress[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 308-310. DOI： 10.11653/syfj2013080308.

摘要

目的: 探讨肾康注射液辅助治疗早期糖尿病肾病(DN)的临床疗效及对患者氧化应激的影响。方法: 66例DN患者随机分为观察组和对照组各33例。对照组严格控制饮食

控制血糖、血压于正常水平

依那普利

5 mg/次

口服

1次/d。观察组在对照组治疗基础上加用肾康注射液

100 mL加入5%葡萄糖300 mL

静脉滴注

1次/d。疗程均为4周。观察两组24 h尿白蛋白排泄率(UAER)

尿β2微球蛋白(β2-MG)

尿微量清蛋白与肌酐的比值(ACR);检测氧化应激指标血清丙二醛(MDA)、超氧化物歧化酶(SOD)及总抗氧化能力(T-AOC)。结果: 治疗后观察组UAER

β2-MG

ACR均低于对照组(P<0.01);治疗后观察组SOD

T-AOC水平明显升高

且高于对照组(P<0.01)

MDA明显下降

且低于对照组(P<0.01);观察组总有效率84.84%优于对照组的63.64%(P<0.05)。结论: 肾康注射液能降低早期糖尿病肾病患者UAER

β2-MG及ACR

提高临床疗效

其机制可能与减少氧化应激反应、增强抗氧化应激能力有关。

Abstract

Objective: To observe the effect of Shenkang injection as an adjunctive treatment on early diabetic nephropathy (DN) and on patients' oxidative stress. Method: Sixty-six DN patients were randomly divided into observation group and control group (n=33 each). The patients in control group were received tight control of diet

blood glucose and blood pressure to maintain normal levels. They were orally taken enalaprilat

5 mg daily. The patients in observation group

on the basis of control group

received Shenkang injection 100 mL mixed with 300 mL 5%glucose

gtt

1 time daily. The treatment course of the two groups lasted 4 weeks. Urinary albumin excretion rates (UAER)

β2-microglobulin (β2-MG)

albumin to creatinine ratio (ACR)

oxidative stress indexes malondialdehyde (MDA)

superoxide dismutase (SOD) and total antioxidant capacity in the two groups were observed. Result: After treatment

UAER

β2-MG and ACR in observation group were lower than those in control group (P<0.01); SOD and T-AOC in observation group were significantly increased and higher than those in control group (P<0.01). MDA in observation group was significantly decreased and lower than that in control group (P<0.01). The total effective rate of observation group (84.84%) was higher than that in control group (63.64%) with a significant difference (P<0.01). Conclusion: Shenkang injection can decrease UAER

β2-MG and ACR in patients with early diabetic nephropathy and improve clinical efficacy

the mechanism of which may be associated with reducing oxidative stress and enhancing anti oxidative stress ability.

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