Objective: To evaluate proper and safe medication in acute phase of ischemic stroke treated with Chinese medicinal injection. Method: Clinical studies involving acute stage of ischemic stroke treated with Chinese medicinal injection published in Chinese from 2012 January to November were electronically searched from CBM

CNKI

and CMJD and assessed by the inclusive and exclusive criteria. The data were extracted

grouped by the category

administration

dialectic medication

combination and safety evolution and then analyzed. Result: Eighty-three papers were included finally. 18 kinds of Chinese medicinal injection were used altogether. All were administrated by intravenous injection once per day

while the daily dose

first use time

and treatment course were different. None of injections was applied by the principle of symptom differentiation. The combination treatment included platelet aggregation inhibitors

anticoagulants

anti-fibrinogen

neuroprotectors

dehydrant

thrombolysis

rehabilitation and high pressure oxygen

except Chinese medicinal injection and decoction of Chinese herbs. Fifty-five studies conducted safety assessment and 40 of them found no adverse reaction. Conclusion: The unrational application of Chinese medical injections existsin in Chinical research. The principle of symptom differentiation and strict conduction with therapeutic indication are suggested in research and clinical application of Chinese medicinal injection. More attention should be paid to safety monitoring and side effect reporting.