Preparation and Dissolution Investigation of  Oil Self-microemulsion

JIANG Nan; LI Ye; CHEN Gang; SHAO A-li; SUN Wen; LI Tong-hui; XIN Yong-jie; LI Dan

doi:10.11653/syfj2013090045

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Preparation and Dissolution Investigation of Oil Self-microemulsion

更新时间：2024-09-23

- Preparation and Dissolution Investigation of Oil Self-microemulsion
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 9, Pages: 45-48(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013090045
  CLC：
- Published：2013
- 稿件说明：
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JIANG Nan, LI Ye, CHEN Gang, et al. Preparation and Dissolution Investigation of Oil Self-microemulsion[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 45-48.
DOI：

JIANG Nan, LI Ye, CHEN Gang, et al. Preparation and Dissolution Investigation of Oil Self-microemulsion[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 45-48. DOI： 10.11653/syfj2013090045.

摘要

目的: 制备鸦胆子油自微乳

并考察其溶出度。方法: 通过溶解度试验、气相色谱法筛选辅料

伪三元相图优化自微乳处方

并进行药物溶出度试验。结果: 鸦胆子油自微乳最优处方为鸦胆子油-辛酸癸酸三甘油酯-聚氧乙烯氢化蓖麻油-聚乙二醇400 12:12:65:11

乳滴粒径<50 nm

15~20 min可基本完全溶出。结论: 鸦胆子油自微乳稳定性良好

提高了用药的顺应性

且制备工艺简单。

Abstract

Objective: To prepare Brucea javanica oil self-microemulsion

and investigate its dissolution. Method: Solubility test and gas chromatography were used to select adjuvants

pseudo-ternary phase diagram was used to optmize prescription of the self-microemulsion

and dissolution test of the self-microemulsion was adopted. Result: Optimum prescription of B. javanica oil self-microemulsion was B. javanica oil-caprylic capric triglyceride-polyoxyethylene hydrogenated castor oil-polyethylene glycol 400 12%: 12%: 65%: 11%

particle size of it was<50 nm and it could be completely dissolved in 15-20 minutes. Conclusion: B. javanica oil self-microemulsion had good stability

it improved medication compliance

and this preparation technology was simple and stable.

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Related Author

JIANG Nan1

LI Ye2

CHEN Gang3

SHAO A-li3

SUN Wen1

LI Tong-hui2

XIN Yong-jie2

LI Dan1

Related Institution

Guangdong Pharmaceutical University

Shaanxi Academy of Traditional Chinese Medicine

Shaanxi University of Chinese Medicine

Dept.of Pharmacy,General Hospital Group Oilfield Hospital of Daqing

Yancheng Institute for Drug Control of Jiangsu Province

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