Research on Plantaginis Semen Extracts Reduce Level of Uric Acid in Hyperuricemia Mice and its Mechanism

ZENG Jin-xiang; WEI Juan; BI Ying; WANG Xiao-yun; ZHU Ji-xiao; ZHU Yu-ye; ZHOU Qiang; LUO Guang-ming; XIONG Hao-zhong

doi:10.11653/syfj2013090173

您当前的位置：

首页 >

文章列表页 >

Research on Plantaginis Semen Extracts Reduce Level of Uric Acid in Hyperuricemia Mice and its Mechanism

更新时间：2024-09-23

- Research on Plantaginis Semen Extracts Reduce Level of Uric Acid in Hyperuricemia Mice and its Mechanism
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 9, Pages: 173-177(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013090173
  CLC：
- Published：2013
- 稿件说明：
移动端阅览
ZENG Jin-xiang, WEI Juan, BI Ying, et al. Research on Plantaginis Semen Extracts Reduce Level of Uric Acid in Hyperuricemia Mice and its Mechanism[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 173-177.
DOI：

ZENG Jin-xiang, WEI Juan, BI Ying, et al. Research on Plantaginis Semen Extracts Reduce Level of Uric Acid in Hyperuricemia Mice and its Mechanism[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 173-177. DOI： 10.11653/syfj2013090173.

摘要

目的: 探讨车前子醇提物对高尿酸血症小鼠血清尿酸水平的影响及降尿酸作用机制。方法: 车前子低、中、高剂量(1.17

2.34

4.68 g·kg-1)和别嘌呤醇(10 mg·kg-1)ig连续7 d

建立小鼠高尿酸血症模型

观测对氧嗪酸钾盐诱导的急性高尿酸血症小鼠血清尿酸与肌酐含量、肝脏黄嘌呤氧化酶(XOD)与腺苷脱氨酶(ADA)的活性、肾脏尿酸转运体(mURAT1) mRNA表达的影响。结果: 与正常组比

模型组小鼠血清尿酸与肌酐含量和肝脏XOD与ADA活性显著增高

并上调肾脏尿酸转运体mURAT1 mRNA的表达。提取物低、中、高剂量组血清尿酸分别为(178.32±10.26)

(148.77±13.59)

(160.28±14.65) μmol·L-1

明显低于模型组(235.65±19.38) μmol·L-1(P<0.01)。血清肌酐分别为(56.12±4.58)

(50.97±3.27)

(52.45±4.66) μmol·L-1

明显低于模型组(107.59±8.32) μmol·L-1(P<0.01)。肝脏XOD活性分别为(23.18±3.72)

(16.96±2.45)

(14.62±3.43) U·g-1

明显低于模型组(24.39±3.58) U·g-1(P<0.05)。ADA活性分别为(4.70±0.44)

(3.89±0.24)

(4.08±0.58) U·mg-1

明显低于模型组(5.92±0.84) U·mg-1(P<0.05

P<0.01)。肾尿酸转运体mURAT1 mRNA的表达分别为1.83±0.12

1.52±0.13

1.72±0.11

明显低于模型组2.22±0.1(P<0.05

P<0.01)。结论: 车前子醇提物能够降低高尿酸血症模型小鼠的血尿酸

改善高尿酸血症小鼠肾脏功能。抑制XOD与ADA活性并下调肾脏尿酸转运体mURAT1 mRNA的表达

是其降低高尿酸血症小鼠血清尿酸水平的可能机制。

Abstract

Objective: To study the effect of Plantaginis Semen extracts (PASEs) on the level of uric acid in hyperuricemia mice and investigate the mechanism. Method: PASEs were administrated to hyperuricemia mice induced by potassium oxonate. The effects of PASEs on serum levels of uric acid

creatinine

and activities of hepatic xanthine oxidase (XOD) and adenosine deaminase (ADA) in hyperuricemia mice were studied. Moreover

The effects of PASEs on renal urate transporter (mURAT1) were analyzed by semi-quantitative RT-PCR method. Result: Different dose groups of observing extract could obviously reduce the level of uric acid

inhibited hepatic xanthine oxidase and denosine deaminase activities in hyperuricemia mice. Furthermore

the PASEs could effectively down-regulate renal mURAT1 level in hyperuricemia mice. And it reversed oxonate-induced elevation in serum creatinine levels of mice. Conclusion: These findings suggested that the PASEs could obviously produce hypourice action by supressing hepatic XOD and ADA to reduce uric acid production and down-regulate renal mURAT1 to decrease urate reabsorption and enhance urate excretion in hyperuricemia mice.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Research on Plantaginis Semen Extracts Reduce Level of Uric Acid in Hyperuricemia Mice and its Mechanism

Effect of Alcohol Extract of Oroxylum indicum on Reducing Uric Acid and Protecting Kidney in Hyperuricemia Mice

The Influences of Biqing Capsule on The Uric Acid Metabolism in Chicken Model of Hyperuricemia

Inhibition Effect of Compound Tufuling Granules on Activity and mRNA of Xanthine Oxidase in Hyperuricemic Rats

Anti-gout Effect of Various Fractions from Plantaginis Semen

Related Author

ZENG Jin-xiang

WEI Juan

BI Ying

WANG Xiao-yun

ZHU Ji-xiao

ZHU Yu-ye

ZHOU Qiang

LUO Guang-ming

Related Institution

Chinese Medicine Germplasm Resource Engineering Technology Research Center of Jiangxi Province,Jiangxi University of Traditional Chinese Medicine

Jiangsu Kanion Pharmaceutical Co. Ltd.

Nanjing University of Chinese Medicine

TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province， Chengdu University of TCM

Hospital of Chengdu University of Traditional Chinese Medicine （TCM）

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰