Effects of  Polysaccharides on Neuronal Loss and Tau Phosphorylation in Frontal Lobe and Hippocampus of SAMP8 Mice

CHEN Xiao-yu; RONG Yan-ping; GUO You-jia; HUANG Ren-bin

doi:10.11653/syfj2013090181

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Effects of Polysaccharides on Neuronal Loss and Tau Phosphorylation in Frontal Lobe and Hippocampus of SAMP8 Mice

更新时间：2024-09-23

- Effects of Polysaccharides on Neuronal Loss and Tau Phosphorylation in Frontal Lobe and Hippocampus of SAMP8 Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 9, Pages: 181-184(2013)
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- DOI：10.11653/syfj2013090181
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- Published：2013
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CHEN Xiao-yu, RONG Yan-ping, GUO You-jia, et al. Effects of Polysaccharides on Neuronal Loss and Tau Phosphorylation in Frontal Lobe and Hippocampus of SAMP8 Mice[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 181-184.
DOI：

CHEN Xiao-yu, RONG Yan-ping, GUO You-jia, et al. Effects of Polysaccharides on Neuronal Loss and Tau Phosphorylation in Frontal Lobe and Hippocampus of SAMP8 Mice[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 181-184. DOI： 10.11653/syfj2013090181.

摘要

目的: 研究玉郎伞多糖(YLSP)对快速老化模型小鼠(SAMP8)额叶、海马神经元丢失和Tau(Ser202)异常磷酸化的影响。方法: 选择6月龄SAMP8

随机分为模型组

石杉碱甲组(0.02 mg·kg-1)

YLSP低、高剂量组(45

180 mg·kg-1)

选择6月龄正常老化小鼠(SAMR1)作为对照组

以上各组每日上午灌胃给药l次

连续40 d

于末次给药的次日采用尼氏染色方法检测额叶和海马神经元缺失率;应用免疫组织化学方法检测额叶和海马Tau(Ser202)磷酸化水平。结果: 模型组额叶、海马神经元缺失率分别为(46.4±8.4)%

(45.5±7.2)%。与模型组相比

石杉碱甲组(35.8±6.7)%

(34.2±5.6)%、YLSP低、高剂量组(35.1±6.4)%

(36.0±4.5)%

(25.6±6.6)%

(26.7±6.1)%额叶、海马神经元缺失率明显降低(P<0.05或P<0.01);模型组额叶、海马pSer202阳性细胞数(92.2±10.7)

(98.6±11.4)个较对照组明显升高(12.3±2.1)

(15.5±2.6)个(P<0.01)

与模型组相比

石杉碱甲组(48.5±6.4)

(56.1±3.3)个、YLSP低、高剂量组(60.7±7.5)

(65.9±8.0);(50.9±5.1)

(53.6±6.7)个的额叶、海马Tau(pSer202)阳性细胞数明显降低(P<0.01)。结论: YLSP降低Tau蛋白异常磷酸化

减少脑部神经元缺失。

Abstract

Objective: To study the effects of Millettia pulcha polysaccharides(YLSP) on neuronal loss and Tau(Ser202) phosphorylation in the frontal lobe and hippocampus of SAMP8 mouse. Method: The SAMP8 mice were adopted as AD model group

and the SAMR1 mice as the control group. Both groups were randomized and given the blank configuration solution. Huperzine(0.02 mg·kg-1) was given to drug-positive group and two YLSP groups were given 45

180 mg·kg-1 respectively

continuous administration for 40 days. In the frontal lobe and hippocampus

neuronal loss and Tau(Ser202) phosphorylation(pser202) were respectively detected by Nissl staining and immunohistochemical method. Result: Comparing with the normal group

the neuronal loss and the number of pSer202 positive cells of the model group were higer(P<0.01) in the frontal lobe and hippocampus. In drug-positive and YLSP groups

the neuronal loss and the number of pSer202 positive cells in the frontal lobe and hippocampus were observed obviously lower (P<0.05 or P<0.01)

comparing with the model group. Conclusion: The abnormal Ser202 phosphorylation is reduced and neuronal loss of brain is ameliorated by YLSP.

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Effects of Millettia pulcha Polysaccharides on Neuronal Loss and Tau Phosphorylation in Frontal Lobe and Hippocampus of SAMP8 Mice

Related Author

CHEN Xiao-yu

RONG Yan-ping

GUO You-jia

HUANG Ren-bin

Related Institution

Department of Pharmacology,Guangxi Medical University

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