Objective: To investigate the benefitial and protective effects of Jili Liangdi Tang (JLLDT) on Streptozotocin (STZ)-induced diabetes mellitus and periphery neuropathic pain. Method: Sixty rats were employed and divided into control

model

positive control (metformin 200 mg·kg-1) and JLLDT low

medium and high dose (16.2

32.4

64.8 g·kg-1) groups evenly. Except of the control group

all the rats were established type II diabetes mellitus induced by intraperitoneal injection of STZ. The rats were intragastric administration of corresponding agent for 4 weeks

while the intake of food and water were recorded. The blood glucose and insulin levels were also measured by blood glucose meter or ELISA kit. Sixty rats were employed and divided into control

model

positive control (gabapentin 120 mg·kg-1) and JLLDT low

medium and high dose (16.2

32.4

64.8 g·kg-1) groups evenly. Except of control group

all the rats were established diabetes mellitus neuropathy induced by intravenous injection of STZ for 7 days. The rats were intragastric administration of corresponding drugs

while the thermal hyperalgesia and mechanical allodynia were measured respectively. Result: JLLDT could decrease the food and water intake and elevate the body weight of diabetic rats significantly in a dose-dependent manner. The blood glucose concentration was deceased to 10.3 mmol·L-1and insulin level was elevated to 0.61 μg·L-1significantly after administration of JLLDT high dose. The three doses of JLLDT could ameliorate the thermal hyperagesia and allodynia of model rats respectively. The analygesia rate in JLLDT high dose reached at 50.3% and 63.2%

respectively (P<0.05). Conclusion: JLLDT exhibits pronounced ability of decrease diabetic blood glucose by elevating insulin secretion

and has protective effect in diabetic periphery neuropathic pain.