Aqueous Extract of  Willd on Atrial Dynamics and ANP Secretion in Beating Rabbit Atria

CUI Hao-zhen; LIU Li-ping

doi:10.11653/syfj2013090256

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Aqueous Extract of Willd on Atrial Dynamics and ANP Secretion in Beating Rabbit Atria

更新时间：2024-09-23

- Aqueous Extract of Willd on Atrial Dynamics and ANP Secretion in Beating Rabbit Atria
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 9, Pages: 256-259(2013)
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- DOI：10.11653/syfj2013090256
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- Published：2013
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CUI Hao-zhen, LIU Li-ping. Aqueous Extract of Willd on Atrial Dynamics and ANP Secretion in Beating Rabbit Atria[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 256-259.
DOI：

CUI Hao-zhen, LIU Li-ping. Aqueous Extract of Willd on Atrial Dynamics and ANP Secretion in Beating Rabbit Atria[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 256-259. DOI： 10.11653/syfj2013090256.

摘要

目的: 观察远志水提取物对家兔心肌收缩力及心房尿钠肽分泌的影响。方法: 采用家兔离体搏动心房灌流模型

观察远志水提取物对家兔心肌收缩力及心房尿钠肽分泌的影响。环磷酸腺苷(cAMP)和心房尿钠肽(ANP)含量的测定均采用放射免疫法。结果: 远志水提取物可使家兔的心房每回搏出量、搏动压和灌流液中cAMP流出量比给药前呈现剂量依赖性递增趋势(P<0.05)。同时

它还可以明显地抑制ANP的分泌(P<0.01)。在阻断β-肾上腺素受体(β-adrenorecptor

β-AR)及选择性阻断β1-AR时能显著抑制远志水提取物对心肌收缩力的增强作用(P<0.05);而选择性阻断β2-AR时却无任何影响。此外

阻断L-型Ca2+通道及选择性抑制蛋白激酶A(PKA)的活性能明显抑制远志水提物对心肌收缩力的增强作用(P<0.05)。结论: 远志水提取物主要通过影响β1-AR-cAMP-Ca2+信号传导途径增强心肌收缩力

并对ANP分泌具有抑制作用。

Abstract

Objective: To investigate the effect of aqueous extract of Polygala tenuifolia(APT) on myocardial contractility and atrial natriuretic peptide (ANP) secretion in beating rabbit atria. Method: The APT-induced changes in atrial dynamics

cAMP efflux and ANP secretion were determined in perfused beating rabbit atria. The changes of cAMP and ANP were measured by radioimmunoassay. Result: APT increased atrial stroke volume

pulse pressure and cAMP efflux in a concentration-dependent manner with inhibition of ANP secretion in beating rabbit atria. The APT-induced positive inotropic effect was significantly blocked by pretreatment with blockade of β and β1-adrenoceptors (AR) (P<0.05) but not β2-AR. Furthermore

the APT-induced changes in myocardial contractility were attenuated by inhibition of L-type Ca2+channel and protein kinase A(PKA) activation with no changes in cAMP efflux. Conclusion: APT could increase atrial dynamics via β1-AR-cAMP-Ca2+signaling and decreases ANP secretion in beating rabbit atria.

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Aqueous Extract of Polygala tenuifolia Willd on Atrial Dynamics and ANP Secretion in Beating Rabbit Atria

Related Author

CUI Hao-zhen1

LIU Li-ping2

Related Institution

Department of Clinic and Basic Medicine,Yanbian University College of Traditional Chinese Medicine,Yanji

Department of Physiology,Yanbian University College of Basic Medicine,Yanji

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