ZHEN Han-shen, LIU Rong, QIU Qin, et al. Anti-inflammatory and Analgesic Effect of [J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 270-273.
DOI:
ZHEN Han-shen, LIU Rong, QIU Qin, et al. Anti-inflammatory and Analgesic Effect of [J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 270-273. DOI: 10.11653/syfj2013090270.
Objective: To study anti-inflammatory and analgesic effect of water extract of Sauropus rostratus. Method: The LD50level of the water extract was determined by modified Karber's method. Dimethylbenzene-induced auricle edema in mice
carrageenan-induced hind paw edema in rats and cotton ball-induced granuloma in mice were respectively performed to investigate the anti-inflammatory effect of the extract (14
7
3.5 g·kg-1). Mouse twisting numbers induced by acetic acid and mouse pain threshold after heat stimulation on hot-plate tests were respectively performed to investigate the analgesic effect of S. rostratus. Result: The LD50level of water extract of S. rostratus. was 68 g·kg-1
the auricle edema induced by dimethylbenzene in mice
catton ball-induced granuloma in mice and carrageenan-induced hind paw edema in rats were inhibited significantly by water extract of S. rostratus. (P<0.05 or P<0.01)
water extract of S. rostratus could remarkably reduce mouse twisting numbers (P<0.05 or P<0.01)
but could not improve pain threshold. Conclusion: The water extract of S. rostratus had anti-inflammatory effect and analgesic effect
the researches could provide a scientific basis for developing and utilizing of S. rostratus.
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Related Author
ZHEN Han-shen1
LIU Rong1
QIU Qin1
JIANG Jian-guo2
YANG Yong-yu2
LUO Xian-qin
LIU Jian-yi
HUANG Si-xing
Related Institution
Second People’s Hospital of Beihai city
Guangxi Traditional Chinese Medical University
Basic Research Center of Integrated Chinese and Western Medicine for Prevention and Treatment of Vascular Diseases,Hunan University of Chinese Medicine
Key Laboratory of Vascular Biology and Translational Medicine,Hunan University of Chinese Medicine
The First Affiliated Hospital of Henan University of Chinese Medicine