Effects of  on Ability of Resistance and Free Radical in Brain Tissue in Exercise-induced Fatigue Rats

GUO Ai-min; CAO Jian-min; ZHU Jing; ZHOU Hai-tao

doi:10.11653/syfj2013090274

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Effects of on Ability of Resistance and Free Radical in Brain Tissue in Exercise-induced Fatigue Rats

更新时间：2024-09-23

- Effects of on Ability of Resistance and Free Radical in Brain Tissue in Exercise-induced Fatigue Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 9, Pages: 274-277(2013)
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- DOI：10.11653/syfj2013090274
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- Published：2013
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GUO Ai-min, CAO Jian-min, ZHU Jing, et al. Effects of on Ability of Resistance and Free Radical in Brain Tissue in Exercise-induced Fatigue Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 274-277.
DOI：

GUO Ai-min, CAO Jian-min, ZHU Jing, et al. Effects of on Ability of Resistance and Free Radical in Brain Tissue in Exercise-induced Fatigue Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 274-277. DOI： 10.11653/syfj2013090274.

摘要

目的: 研究菟丝子对大鼠抗运动性疲劳能力及脑组织自由基的影响。方法: 以大强度耐力训练大鼠为模型

65只42 d龄雄性Wistar大鼠为对象

随机分为5组:静止对照组、运动对照组、运动+低剂量菟丝子组、运动+中剂量菟丝子组、运动+高剂量菟丝子组

每组12只。采用专业灌胃器每天灌胃给药(ig)1次。低、中、高剂量组ig剂量分别为1.16

2.32

6.96 g·kg-1·d-1

ig体积为5 mL·kg-1。静止对照组和运动对照组ig等量生理盐水。6周力竭游泳训练。末次训练后24 h

测定体重、力竭游泳时间及脑组织中超氧化物歧化酶(SOD)等与疲劳作用相关的指标。结果: 运动+菟丝子各剂量组体重均大于运动对照组(P<0.05)

力竭游泳时间均长于运动对照组(P<0.01)。力竭游泳导致大鼠脑组织中MDA含量显著升高。运动对照组及运动+菟丝子各组分别升高至(6.46±0.21)

(5.17±0.26)

(4.89±0.19)

(4.76±0.33)μmol·L

但运动+菟丝子各组明显低于运动对照组(P<0.01)。SOD

GSH-Px活性显著下降。运动对照组及运动+菟丝子各组SOD分别下降至(207.35±12.27)

(245.85±11.31)

(253.98±11.24)

(261.31±12.69)U·mL-1

GSH-Px分别下降至(52.24±5.35)

(68.57±5.83)

(71.96±5.96)

(73.38±5.15)U·mg-1

但运动+菟丝子各剂量组明显高于运动对照组(P<0.01)。结论: 菟丝子具有提高脑组织抗氧化酶活性的作用

从而抑制大强度力竭运动造成的脑组织氧化损伤

延缓疲劳发生。

Abstract

Objective: To study the effects of Cuscuta chinensis on free radical in brain tissue and ability of resistance in exercise-induced fatigue rats. Method: The high-intensity endurance training in rats was used to establish exercise-induced fatigue model.The modeling rats were divided into the 4 groups:model group

low

medium and high groups of C. chinensis group (1.16

2.32

6.96 g·kg-1·d-1

ig). Another group without exercise as a control group was set after 6 weeks of exhaustive swimming training. 24 h after the last training

weight

exhaustive swimming time and malondialdehyde(MDA)

superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px) in brain were observed. Result: The weight in C. chinensis groups was increased group(P<0.05)

swimming time became longer (P<0.01) compared with model.In C. chinensis groups MDA were decreased compared with model group (P<0.01)

and SOD

GSH-Px activity was significantly increasee. Conclusion: C. chinensis has the antioxidation action and increase ability of resistance on exercise-induced fatigue

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Related Author

GUO Ai-min1

CAO Jian-min2

ZHU Jing1

ZHOU Hai-tao3

Jia-hui FANG

Jia-wei LIU

Yu-xin JIANG

Shu JING

Related Institution

Beijing Union University

Beijing Sport University

China University of Petroleum

College of Pharmacy， Beihua University

Affiliated Hospital of Beihua University

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