WANG Wen-xiang, XIONG Xiao-bin. Effect of Astragalosides Extract on Liver Fibrosis Induced by Bovine Serum Albumin in Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 277-280.
DOI:
WANG Wen-xiang, XIONG Xiao-bin. Effect of Astragalosides Extract on Liver Fibrosis Induced by Bovine Serum Albumin in Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 277-280. DOI: 10.11653/syfj2013090277.
Effect of Astragalosides Extract on Liver Fibrosis Induced by Bovine Serum Albumin in Rats
Objective: To observe effect of astragalosides extract on liver fibrosis in rats. Method: Sixty SD rats were randomly divided into six groups: normal control group (A)
model group (B)
colchicine group(C)
low-dose astragalosides group(D)
middle-dose astragalosides group (E) and high-dose astragalosides group (F).Liver fibrosis model in rat was produced with bovine serum albumin(ABS). Group C received colchicine (0.1 mg·kg-1·d-1);group D
E
F received low-dose astragalosides (15 mg·kg-1·d-1)
middle-dose astragalosides (30 mg·kg-1·d-1) and high-dose astragalosides (60 mg·kg-1·d-1) ig respectively. After 55 days
serum levels of serum total protein (TP)
albumin(ALB)
alanine aminotransferase(ALT)
aspartate aminotransferase(AST)
hyaluronic acid(HA)
laminin(LN)
type Ⅲ procollagen(PC-Ⅲ) and type Ⅳ collagen (Ⅳ-C) in different groups were detected. Result: Compared with model group
levels of ALT
AST
HA
LN
PC-Ⅲand Ⅳ-C in the treatment groups were obviously improved.It had significantly statistical difference(P<0.05
P<0.01).Pathological result showed that the liver fibrosis in the treatment groups was signiflcantly attanuated. Conclusion: These results suggested that astragalosides shows obvious effect against rat hepatic fibrosis.
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Related Author
WANG Wen-xiang
XIONG Xiao-bin
WANG Xiaojie
ZHANG Heng
LIU Sutong
ZHANG Lihui
ZHAO Wenxia
WANG Fei
Related Institution
Beijing Rongchang Medicin R&D Institute,Beijng
Henan General Hospital
The First Affiliated Hospital of Henan University of Chinese Medicine
The First Clinical Medical College of Henan University of Chinese Medicine
Graduate School of Anhui University of Chinese Medicine