WANG Hai-yan, ZHANG Li-yun, MENG Xian-ping, et al. Efficacy of Ganglioside Supplemented by Danshen Injection in Treatment of Neonatal Hypoxic-ischemic Encephalopathy[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 330-332.
DOI:
WANG Hai-yan, ZHANG Li-yun, MENG Xian-ping, et al. Efficacy of Ganglioside Supplemented by Danshen Injection in Treatment of Neonatal Hypoxic-ischemic Encephalopathy[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 330-332. DOI: 10.11653/syfj2013090330.
Efficacy of Ganglioside Supplemented by Danshen Injection in Treatment of Neonatal Hypoxic-ischemic Encephalopathy
Objective: To investigate the efficacy of ganglioside supplemented by Danshen injection in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE). Method: Seventy neonates with HIE were randomly divided into observation group and the control group
the control group were given symptomatic and supportive treatment
the observation group was received ganglioside and Danshen injection. The efficacy
neonatal behavioral neurological assessment(NBNA) scores changes and the improvement of convulsions
disturbance of consciousness
abnormal primitive reflexes and dystonia were observed and compared. Result: The effective rate of the observation group was 94.29%
significantly higher than that of the control group (77.14%)
the difference had statistically significant (P<0.05). After one week and two weeks of treatment
the NBNA scores of two groups were significantly improved compared with before treatment
there were statistically significant (P<0.05). Compared with the control group
NBNA scores in the observation group after treatment were improved significantly (P<0.05). The time of convulsions
disturbance of consciousness
the original abnormal reflexes and dystonia were improved in the observation group significantly compared with those of the control group (P<0.05). Conclusion: Ganglioside supplemented by Danshen injection is effective in the treatment of HIE