Optimization of Extraction Technology of Hesperidin and Nobiletin from  by Box-Behnken Design-Response Surface Methodology

WEI Zheng; YANG Li; LI Ming; PENG Yue; YIN Ling; LIU Rong; FAN Dan-qing; LIU You-ping

doi:10.11653/syfj2013100017

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Optimization of Extraction Technology of Hesperidin and Nobiletin from by Box-Behnken Design-Response Surface Methodology

更新时间：2024-01-04

- Optimization of Extraction Technology of Hesperidin and Nobiletin from by Box-Behnken Design-Response Surface Methodology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 10, Pages: 17-20(2013)
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- DOI：10.11653/syfj2013100017
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- Published：2013
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WEI Zheng, YANG Li, LI Ming, et al. Optimization of Extraction Technology of Hesperidin and Nobiletin from by Box-Behnken Design-Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(10): 17-20.
DOI：

WEI Zheng, YANG Li, LI Ming, et al. Optimization of Extraction Technology of Hesperidin and Nobiletin from by Box-Behnken Design-Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(10): 17-20. DOI： 10.11653/syfj2013100017.

摘要

目的: 通过Box-Behnken效应面法优化陈皮中橙皮苷及川陈皮素的提取工艺。方法: 采用HPLC测定橙皮苷及川陈皮素含量

以橙皮苷及川陈皮素提取率的总评"归一值"为指标

通过Box-Behnken试验考察提取温度、液料比、提取时间对提取工艺的影响

对结果进行二项式方程拟合

利用效应面法优化提取工艺并进行预测分析。结果: 最佳提取工艺为温度77 ℃

液料比19:1

提取1.6 h

乙醇体积分数70%;预测值与验证值偏差较小(<5%)。结论: 优选的提取工艺稳定可行

实际值与预测值吻合度高

预测性良好。

Abstract

Objective: To optimize extraction process of hesperidin and nobiletin from Citrus reticulata by Box-Behnken design-response surface method. Method: The content of hesperidin and nobiletin was determined by HPLC.Independent variables were extraction temperature

liquid-solid ratio and extraction time

dependent variable was the overall desirability of extraction rate of hesperidin and nobiletin.No-linear mathematic models was used to estimate relationship between independent and dependent variables

response surface methodology was used to optimize extraction process

prediction was carried out by comparing the observed and predicted values. Result: Optimum extraction technology was as following:reflux extracted 1.6 h with 19 times the amount of 70% ethanol at 77 ℃.Deviation between the observed and predicted values was small(<5%). Conclusion: This optimized extraction technology was stable and feasible with high predictability.

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Related Institution

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

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Institute of Basic Research in Clinical Medicine，China Academy of Chinese Medical Sciences

Chongqing Three Gorges Medical College

Shandong University of Traditional Chinese Medicine

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