Objective: To establish a new method for simultaneous determination and comparison of the content of camphor

borneol and gaultherolin in compound Nanxing pain patch formed with different stroma by GC. Method: DB-WAX capillary column(0.53 m×30 mm

1.00 μm) and FID were used

column temperature raised by a program of the beginning temperature at 90 ℃

then increased to 120 ℃ at the rate of 1 ℃·min-1

the inlet temperature was 230 ℃ and the detector of FID temperature was 250 ℃.The content of four kinds of volatile components in the solvent and emulsion type pressure-sensitive adhesive patch was compared by statistical software. Result: The linear ranges of camphor

borneol

isoborneol and gaultherolin were 18.80-75.14(r=0.999 8)

11.50-46.14(r=0.999 7)

13.50-54.08(r=0.999 8)

99.60-3 982.40(r=0.999 7) g·L-1

respectively.The average recoveries of them were 100.56%

100.60%

100.54%

99.79%

respectively

and all RSD were less than 3%(n=6).The content of 4 kinds of volatile components in the solvent type pressure-sensitive adhesive patch were more than the emulsion type pressure-sensitive adhesive patch

which were compared by t-test. Conclusion: This established method was sensitive

simple and accurate.It could adopt to simultaneously determine 4 kinds of volatile components in compound Nanxing pain patch

and compound Nanxing pain patch was more superior to be prepared as solvent transdermal patch.