Investigation of  Percutaneous Absorption of  Powder Dressing with Vinegar

WANG Sen; LEI Xiao-juan; ZHU Wei-feng; HUANG Zhao-guang

doi:10.11653/syfj2013100031

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Investigation of Percutaneous Absorption of Powder Dressing with Vinegar

更新时间：2024-01-04

- Investigation of Percutaneous Absorption of Powder Dressing with Vinegar
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 10, Pages: 31-34(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013100031
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- Published：2013
- 稿件说明：
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WANG Sen, LEI Xiao-juan, ZHU Wei-feng, et al. Investigation of Percutaneous Absorption of Powder Dressing with Vinegar[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(10): 31-34.
DOI：

WANG Sen, LEI Xiao-juan, ZHU Wei-feng, et al. Investigation of Percutaneous Absorption of Powder Dressing with Vinegar[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(10): 31-34. DOI： 10.11653/syfj2013100031.

摘要

目的: 考察吴茱萸粉末醋调敷豚鼠的体外透皮渗透特性。方法: 采用改良Franz扩散池

以离体豚鼠皮肤为透皮屏障

通过体外透皮吸收试验

用HPLC检测接收液中吴茱萸碱和吴茱萸次碱的质量浓度

计算累积透过量、渗透速率

建立渗透曲线方程。结果: 茱萸碱和吴茱萸次碱的透皮吸收速率分别为0.34

0.19 μg·cm-2·h-1

24 h累积透过量分别为7.78

4.42 μg·cm-2。结论: 醋调吴茱萸粉末中吴茱萸碱和吴茱萸次碱具有良好的体外透皮释放性能

为吴茱萸经皮吸收制剂的研究提供参考。

Abstract

Objective: To investigate in vitro transdermal permeability of Evodia rutaecarpa powder vinegar dressing in guinea pigs. Method: Modified Franz diffusion cell was adopted

with isolated guinea pig skin as transdermal barrier

through in vitro percutaneous absorption test

the content of evodiamine and rutaecarpine was determined by HPLC

then cumulative amount and permeation rate

in order to obtain penetration curve equation. Result: Transdermal absorption rate of evodiamine and rutaecarpine were 0.34

0.19 μg·cm-2·h-1

the cumulative amount of them in 24 h were 7.78

4.42 μg·cm-2. Conclusion: Evodiamine and rutaecarpine from E. rutaecarpa powder dressing vinegar had good in vitro transdermal absorption characteristics

it could provide a reference for study on percutaneous absorption preparation of E. rutaecarpa.

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Related Institution

China State Institute of Pharmaceutical Industry

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Traditional Chinese Medicine （TCM） Regulating Metabolic Diseases Key Laboratory of Sichuan Province， Hospital of Chengdu University of TCM

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