Optimization of Multiple Composite Penetration Enhancers for Bitong Cataplasm

LI Zhi-yong; LUO Xiao-shan; SUN Dong-mei; WANG Luo-lin; LUO Wen-hui

doi:10.11653/syfj2013100042

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Optimization of Multiple Composite Penetration Enhancers for Bitong Cataplasm

更新时间：2024-01-04

- Optimization of Multiple Composite Penetration Enhancers for Bitong Cataplasm
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 10, Pages: 42-45(2013)
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- DOI：10.11653/syfj2013100042
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- Published：2013
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LI Zhi-yong, LUO Xiao-shan, SUN Dong-mei, et al. Optimization of Multiple Composite Penetration Enhancers for Bitong Cataplasm[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(10): 42-45.
DOI：

LI Zhi-yong, LUO Xiao-shan, SUN Dong-mei, et al. Optimization of Multiple Composite Penetration Enhancers for Bitong Cataplasm[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(10): 42-45. DOI： 10.11653/syfj2013100042.

摘要

目的: 优选痹痛巴布剂中多元复合透皮促进剂(MCPE)。方法: 采用Frans扩散池法进行体外透皮吸收试验

以单位面积累积释放量为指标

采用单因素试验考察1%冰片(BO)

1.5%氮酮(AZ)

5%丙二醇(PG)及1%薄荷脑(MT)对痹痛巴布剂中桂皮醛体外经皮渗透的影响;以透皮速率、外观及初黏力的综合评分为指标

通过U7(74)均匀设计法优化MCPE的配比。结果: 1%MT

1%BO

5%PG及1.5%AZ对痹痛巴布剂中桂皮醛的透皮渗透均具有不同程度的促进作用;MCPE最佳BO-AZ-PG-MT配比为1.33%:1.90%:6.40%:1.30%。结论: 优选的MCPE可明显提高痹痛巴布剂的透皮速率常数

同时对其外观质量及初黏力的影响较小。

Abstract

Objective: To optimize multiple composite penetration enhancers(MCPE) of Bitong cataplasm. Method: In vitro percutaneous absorption test was used by Frans diffusion cell method

with cumulative release per unit area as index

effects of 1% borneol(BO)

1.5% azone(AZ)

5% propylene glycol(PG) and 1% menthol(MT) on in vitro percutaneous penetration of cinnamic aldedyde in Bitong cataplasm were investigated by single factor test;With composite score of permeation rate

appearance and initial adhesion as index

U7(74) uniform design was used to optimize the prescription of MCPE. Result: 1% BO

1.5% AZ

5% PG and 1% MT had different degrees role in promoting for transdermal penetration of cinnamic aldehyde in Bitong cataplasm;Optimum ratio of MCPE was BO-AZ-PG-MT=1.33%:1.90%:6.40%:1.30%. Conclusion: This optimized MCPE could significantly improve transdermal rate constant of Bitong cataplasm

while effects on appearance and initial adhesion was small.

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Related Institution

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College of Integrated Traditional Chinese and Western Medicine，Medical School， Hunan University of Chinese Medicine

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