Determination and Stability of Muscone in Jiuwei Fangwensan

ZHAI Yong-song; WANG Da-wei; LI Peng-yue; LIU Yu; SHAO Jie; HUANG Fu-kai

doi:10.11653/syfj2013100128

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Determination and Stability of Muscone in Jiuwei Fangwensan

更新时间：2024-01-04

- Determination and Stability of Muscone in Jiuwei Fangwensan
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 10, Pages: 128-130(2013)
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- DOI：10.11653/syfj2013100128
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- Published：2013
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ZHAI Yong-song, WANG Da-wei, LI Peng-yue, et al. Determination and Stability of Muscone in Jiuwei Fangwensan[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(10): 128-130.
DOI：

ZHAI Yong-song, WANG Da-wei, LI Peng-yue, et al. Determination and Stability of Muscone in Jiuwei Fangwensan[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(10): 128-130. DOI： 10.11653/syfj2013100128.

摘要

目的: 建立九味防瘟散中麝香酮含量测定方法

以麝香酮为指标研究该制剂的稳定性。方法: 以HPLC-MS法测定麝香酮的含量;研究九味防瘟散在不同温度和包装条件下的稳定性。结果: 麝香酮浓度在0.2～20 mg·L-1线性关系良好(r=0.999 9)

精密度、回收率、稳定性、重复性均符合实验要求。稳定性方面

去外包装组麝香酮损失速率>包装组

35 ℃时麝香酮损失速率>4 ℃

密闭包装组麝香酮损失速率>密封包装组。结论: HPLC-MS法测定九味防瘟散中的麝香酮含量灵敏、快捷、简便、准确。九味防瘟散须在冷处密封条件下保存。

Abstract

Objective: To establish the determination methods for muscone in Jiuwei Fangwensan and to study the stability of the formulation. Method: Firstly

the HPLC-MS method for muscone in Jiuwei Fangwensan was established. In addition

the effect of temperature and sealed condition on the stability of Jiuwei Fangwensan was evaluated. Result: Muscone showed a good linear relationship in the range of 0.2-20 mg·L-1(r=0.999 9).Precision

recovery rate

stability

repeatability were in line with the experimental requirements. Stability experiment showed that the loss rate of muscone in group without package was faster than group with package. Meanwhile

the loss rate of muscone in 35 ℃ and well package groups was faster than 4 ℃ and tightly package groups

respectively. Conclusion: The method is sensitive

accurate and could be used in the quality control and the stability study of Jiuwei Fangwensan. Muscone in the formulation is basically stable at 4 ℃ and tightly packaged condition.

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